Search

Search Results

1. Society on NeuroImmune Pharmacology COVID-19 Virtual Workshop

   Abstract

   This brief report collects the program and abstracts of the Society on NeuroImmune Pharmacology (SNIP) COVID-19 Virtual Workshop held on...

   Santosh Kumar, Gurudutt Pendyala, ... Sulie L. Chang in Journal of Neuroimmune Pharmacology

   Article 28 June 2021
   

2. Biological Sample Collection from Experimental Animals

   Biological samples such as blood, urine and other body fluids are collected from laboratory animals for specific purposes. The methods used for the...

   Subramani Parasuraman, Ramasamy Raveendran in Introduction to Basics of Pharmacology and Toxicology

   Chapter 2022
   

3. Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice

   Transmembrane prolyl 4-hydroxylase (P4H-TM) is an enigmatic enzyme whose cellular function and primary substrate remain to be identified. Its...

   Tuulia Ala-Nisula, Riikka Halmetoja, ... Elitsa Y. Dimova in Pflügers Archiv - European Journal of Physiology

   Article Open access 24 February 2024
   

4. Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease

   Background

   Alzheimer’s disease (AD) is notably associated with cognitive decline resulting from impaired function of hippocampal and cortical areas;...

   Lisa S. Robison, Olivia J. Gannon, ... Kristen L. Zuloaga in Biology of Sex Differences

   Article Open access 09 August 2023
   

5. Extracellular Matrix Glycation and Crosslinking in Mammary Tumor Progression

   Breast cancer progression is accompanied by profound extracellular matrix (ECM) remodeling. A greater abundance of aligned fibrillar collagen is...

   Jason J. Northey, Valerie M. Weaver in The Tumor Microenvironment

   Protocol 2023
   

6. Rat Models of Cardiorenal Syndrome and Methods for Functional Assessment

   Cardiorenal syndrome (CRS) is a clinical disorder involving combined heart and kidney dysfunction, which leads to poor clinical outcomes. To...

   Andrew R. Kompa in Experimental Models of Cardiovascular Diseases

   Protocol 2024
   

7. Insertion of a chimeric retrotransposon sequence in mouse Axin1 locus causes metastable kinky tail phenotype

   Background

   Transposable elements (TEs) make up > 50% of the human genome, and the majority of retrotransposon insertions are truncated and many are...

   Zhuqing Wang, Hayden McSwiggin, ... Wei Yan in Mobile DNA

   Article Open access 03 May 2019
   

8. miRNA Theranostic Nanoparticles Promote Pancreatic Beta Cell Proliferation in Type 1 Diabetes Model

   Type 1 diabetes (T1D) is a chronic autoimmune disorder which affects the insulin-producing beta cells in the pancreas. A variety of strategies,...

   Saumya Nigam, Anna Moore, ** Wang in Type-1 Diabetes

   Protocol 2023
   

9. Regulation of Presynaptic Release Machinery by Cell Adhesion Molecules

   The synapse is a highly specialized asymmetric structure that transmits and stores information in the brain. The size of pre- and postsynaptic...

   Motokazu Uchigashima, Yasunori Hayashi, Kensuke Futai in Molecular Mechanisms of Neurotransmitter Release

   Chapter 2023
   

10. Behavioral and Metabolic Effects of ABCG4 KO in the APP^swe,Ind (J9) Mouse Model of Alzheimer’s Disease

    The pathogenesis of Alzheimer’s disease (AD) is complex and involves an imbalance between production and clearance of amyloid-ß peptides (Aß),...

    Vincent Fong, Babunageswararao Kanuri, ... Shailendra B. Patel in Journal of Molecular Neuroscience

    Article Open access 26 April 2024
    

11. Exercise 6: Clearance of Bacteria from Mouse Blood by the Reticuloendothelial System (RES)

    The reticuloendothelial system (RES) also known as the mononuclear phagocyte system (MPS) is a functional network of phagocytic tissue macrophages....

    Tobili Y. Sam-Yellowe in Immunology: Overview and Laboratory Manual

    Chapter 2021
    

12. Fundamentals of Pharmacokinetics to Assess the Correlation Between Plasma Drug Concentrations and Different Blood Sampling Methods

    Purpose

    Various blood collection methods were developed and used in the pharmacokinetic evaluation of drugs. However, the influence of different blood...

    Wei-Ching Chen, Pei-Wei Huang, ... Hong-Jaan Wang in Pharmaceutical Research

    Article 02 January 2019
    

13. Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage

    Paraquat, a superoxide generator, can damage the cochlea causing an ototoxic hearing loss. The purpose of the study was to determine if deletion of Bak ...

    Dalian Ding, Tomas Prolla, ... Richard Salvi in Neurotoxicity Research

    Article 26 April 2021
    

14. Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice

    Ketamine is used as an analgesic adjuvant in patients with chronic cancer–related pain. However, ketamine’s short half-life requires frequent dose...

    Weizhi Xu, Faheem Maqbool, ... Felicity Y. Han in Drug Delivery and Translational Research

    Article 20 November 2021
    

15. The NDUFS4 Knockout Mouse: A Dual Threat Model of Childhood Mitochondrial Disease and Normative Aging

    Mice missing the Complex I subunit NADH:Ubiquinone Oxidoreductase Fe-S Protein 4 (NDUFS4) of the electron transport chain are a leading model of the...

    Anthony S. Grillo, Alessandro Bitto, Matt Kaeberlein in Mitochondrial Medicine

    Protocol 2021
    

16. Amyloid plaques and normal ageing have differential effects on microglial Ca²⁺ activity in the mouse brain

    In microglia, changes in intracellular calcium concentration ([Ca ²⁺ ] _i ) may regulate process motility, inflammasome activation, and phagocytosis....

    Pablo Izquierdo, Renaud B. Jolivet, ... Christian Madry in Pflügers Archiv - European Journal of Physiology

    Article Open access 15 November 2023
    

17. An Introduction to Computational Pipelines for Analyzing Untargeted Metabolomics Data for Leishmaniasis

    Metabolomics helps us to understand the metabolism of biological systems and also metabolic interaction between host and parasites. This chapter...

    Anita Verma, Arunangshu Das, Chinmay K. Mukhopadhyay in Integrated Omics Approaches to Infectious Diseases

    Chapter 2021
    

18. Blunted Amphetamine-induced Reinforcing Behaviors and Transporter Downregulation in Knock-in Mice Carrying Alanine Mutations at Threonine-258 and Serine-259 of Norepinephrine Transporter

    Altered amine transporter function, phosphorylation, and association with interacting proteins are evident in animals with a history of...

    Durairaj Ragu Varman, Padmanabhan Mannangatti, ... Lankupalle D. Jayanthi in Journal of Molecular Neuroscience

    Article 19 July 2022
    

19. Red blood cell-derived arginase release in hemolytic uremic syndrome

    Background

    Hemolysis is a cardinal feature of hemolytic uremic syndrome (HUS) and during hemolysis excess arginase 1 is released from red blood cells....

    Niklas Friberg, Ida Arvidsson, ... Diana Karpman in Journal of Translational Medicine

    Article Open access 04 January 2024
    

20. Chemoprophylaxis vaccination with a Plasmodium liver stage autophagy mutant affords enhanced and long-lasting protection

    Genetically attenuated sporozoite vaccines can elicit long-lasting protection against malaria but pose risks of breakthrough infection....

    Tejram Sahu, Ella J. Gehrke, ... Isabelle Coppens in npj Vaccines

    Article Open access 10 August 2021