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Diagnostic value of combining preoperative inflammatory markers ratios with CA199 for patients with early-stage pancreatic cancer
BackgroundAn early diagnosis of pancreatic cancer (PC) is extremely difficult because of the lack of sensitive liquid biopsy methods and effective...
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Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis
Women with germline BRCA1 mutations ( BRCA1 +/mut ) have increased risk for hereditary breast cancer. Cancer initiation in BRCA1 +/mut is associated with...
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Androgen and Oestrogen Signalling Pathways in Prostate Hyperplastic Tissues: Opportunities for Therapeutic Targeting from Multiple Angles
Benign prostatic hyperplasia (BPH), a non-malignant neoplasm in ageing men, is the most frequent cause of urinary flow obstructions at the bladder...
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Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions
BackgroundDespite therapeutic advances, once a cancer has metastasized to the bone, it represents a highly morbid and lethal disease. One third of...
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The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
BackgroundTumor-associated macrophages (TAMs) are associated with unfavorable patient prognosis in many cancer types. However, TAMs are a...
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Mechanisms Underlying Tumor-Associated Macrophages (TAMs)-Facilitated Metastasis
Metastasis is responsible for more than 90% of cancer deaths, but remains the least understood stage of tumor progression. The tumor microenvironment...
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Enhanced epithelial-mesenchymal transition signatures are linked with adverse tumor microenvironment, angiogenesis and worse survival in gastric cancer
Epithelial-mesenchymal transition (EMT) is a crucial mechanism that facilitates cancer cell metastasis. Despite its importance, the clinical...
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The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy
Immune checkpoint blockade has recently proven effective in subsets of patients with esophageal adenocarcinoma (EAC) but little is known regarding...
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Prognostic Evaluation of Ductal Carcinoma in Situ Lesions Using Monoclonal Antibodies and Machine Learning
An important goal of biomedical research has been the prediction of cancer recurrences at the earliest possible times. We now review the first method...
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Repurposing Metformin for periodontal disease management as a form of oral-systemic preventive medicine
BackgroundDespite the improvements in treatment over the last decades, periodontal disease (PD) affects millions of people around the world and the...
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A spatially resolved atlas of the human lung characterizes a gland-associated immune niche
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well...
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Spatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis
BackgroundIntraductal papillary neoplasms (IPN) and biliary epithelial neoplasia (BilIN) are well‐defined precursor lesions of biliary tract...
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Integrative evaluation and experimental validation of the immune-modulating potential of dysregulated extracellular matrix genes in high-grade serous ovarian cancer prognosis
BackgroundHigh-grade serous ovarian cancer (HGSOC) is a challenging malignancy characterized by complex interactions between tumor cells and the...
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A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans
BackgroundDuring pregnancy, the mouse mammary ductal epithelium branches and grows into the surrounding stroma, requiring extensive extracellular...
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Eta polycaprolactone (ε-PCL) implants appear to cause a partial differentiation of breast cancer lung metastasis in a murine model
BackgroundCells in every epithelium can be roughly divided in three compartments: stem cell (SC) compartment, transient amplifying cell (TA)...
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DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets
BackgroundWhile single-cell transcriptional profiling has greatly increased our capacity to interrogate biology, accurate cell classification within...
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HOXC6 impacts epithelial-mesenchymal transition and the immune microenvironment through gene transcription in gliomas
BackgroundGliomas are the most common primary malignant tumours of the central nervous system (CNS). To improve the prognosis of glioma, it is...
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Prognostic factors, oncological treatment and outcomes of uterine sarcoma: 10 years’ clinical experience from a tertiary care center in Pakistan
BackgroundUterine sarcoma is an uncommon aggressive malignancy. Optimal management and prognostic factors have yet to be well recognized due to their...
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Transcript and protein signatures derived from shared molecular interactions across cancers are associated with mortality
BackgroundCharacterization of shared cancer mechanisms have been proposed to improve therapy strategies and prognosis. Here, we aimed to identify...
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Altered splicing associated with the pathology of inflammatory bowel disease
BackgroundAberrant splicing of individual genes is a well-known mechanism promoting pathology for a wide range of conditions, but disease is less...
