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Molecular Insights and Risk Factors Associated with Small and Non-small Cell Lung Cancer
With approximately two million new cases and 1.76 million deaths annually, lung cancer is one of the most commonly found malignancies and the main...
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Immunotherapy for Non-small Cell Lung Cancer
The introduction of immunotherapies in the treatment of metastatic lung cancer has brought a major change to oncology practices with a high impact on...
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Hippo pathway in non-small cell lung cancer: mechanisms, potential targets, and biomarkers
Lung cancer is the primary contributor to cancer-related deaths globally, and non-small cell lung cancer (NSCLC) constitutes around 85% of all lung...
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Lung Cancer
Cancers of the lung account for a large fraction of all cancer deaths worldwide. The vast majority are caused by carcinogens from cigarette smoke....
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Introduction to Lung Cancer
Lung cancer is the second most common malignancy in both men and women. In total, 90% of lung cancer–related fatalities are caused by smoking, which...
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The Ribonuclease ZC3H12A is required for self-inflicted DNA breaks after DNA damage in small cell lung cancer cells
Radiotherapy is the first line treatment for small cell lung cancer (SCLC); However, radio-resistance accompanies with the treatment and hampers the...
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Recent progress of small-molecule of RET inhibitors against Non-small cell lung cancer
Since the oncogenic rearranged during transfection (RET) gene fusion was discovered in non-small cell lung cancer (NSCLC) in 2012, multiple-targeted...
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Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer
BackgroundLung cancer is the most lethal cancer, and 85% of cases are classified as non-small cell lung cancer (NSCLC). Metabolic rewiring is a...
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Small cells – big issues: biological implications and preclinical advancements in small cell lung cancer
Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest human malignancies, as a homogeneous disease. Accordingly,...
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Current pharmacologic treatment of brain metastasis in non-small cell lung cancer
Lung cancer is a type of cancer that can metastasize to the lungs, brain, bones, liver, adrenal glands, and other organs; however, the occurrence of...
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Circ_BLNK is a Unique Molecular Marker in Non-small Cell Lung Cancer
Non-small cell lung cancer (NSCLC) patients are characterized by distant metastasis and poor prognosis. Growing evidence has implied that circular...
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Systematic analysis of IGF2BP family members in non-small-cell lung cancer
BackgroundThe insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2, and IGF2BP3) are known to be involved in...
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Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer
Kirsten rat sarcoma viral oncogene homologue (KRAS) is a frequent oncogenic driver of solid tumors, including non-small cell lung cancer (NSCLC). The...
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ACADL-YAP axis activity in non-small cell lung cancer carcinogenicity
BackgroundThe role of Acyl-CoA dehydrogenase long chain (ACADL) in different tumor types had different inhibiting or promoting effect. However, its...
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Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer
AbstractCancer-associated fibroblasts (CAFs) are important components in the tumor microenvironment, and we sought to identify effective therapeutic...
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circRNA-CPA4 Regulates Cell Proliferation and Apoptosis of Non-small Cell Lung Cancer via the miR-1183/PDPK1 Axis
Non-small-cell lung cancer (NSCLC) stands as a prevalent subtype of lung cancer, with circular RNAs emerging as key players in cancer development....
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LINC02159 promotes non-small cell lung cancer progression via ALYREF/YAP1 signaling
Lung cancer is the leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) have emerged as key regulators of cancer...
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Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer
Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies...
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A novel intranasal peptide vaccine inhibits non-small cell lung cancer with KRAS mutation
KRAS mutations occur commonly in the lung and can lead to the development of non-small cell lung cancer (NSCLC). While the mutated KRAS protein is a...
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Immunotherapy for Small Cell Lung Cancer
Small cell lung cancer (SCLC) accounts for approximately 15% of lung cancers. The disease is defined by a close association with smoking, an...