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Purinergic Signaling: An Overview
This chapter summarizes some of the evidence that originated the purinergic signaling discovery from the first identification of purines and...
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Inter- and Intracellular Signaling Pathways
Cardiovascular diseases, both congenital and acquired, are the leading cause of death worldwide, associated with significant health consequences and...
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Purinergic Signaling in Depression
Depressive disorders are thought to result from a complex interplay between genetic and environmental factors, of which stress seems to play a...
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Target Hyperactive ERK Signaling for Cancer Therapy
Hyperactive ERK signaling has a well-defined role in cancer biology. Targeting this signaling node for cancer therapy has achieved promising outcomes...
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Purinergic Signaling in the Cerebellum
Purinergic signaling is a complex and evolutionarily conserved mechanism of extracellular communication involved in many physiological and...
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Redox Signaling
A diverse redox microenvironment exists in healthy cells and cancer cells. Homeostasis of the redox microenvironment of a healthy cell is severely...
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Redox Signaling
A diverse redox microenvironment exists in healthy cells and cancer cells. Homeostasis of the redox microenvironment of a healthy cell is severely...
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Sonic Hedgehog Cell Signaling Pathway and Medulloblastoma
The Sonic hedgehog cell signaling pathway is responsible for the cellular differentiation of embryonic cells. Interestingly, different parts of the...
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Purinergic Signaling in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder estimated to affect 1:36 individuals, characterized by impairments...
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Purinergic Signaling in Brain Tumors
Brain tumors are primary or metastatic tumors that proliferate in the brain tissue itself or surrounding tissues, such as pituitary and pineal...
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Triptolide activates the Nrf2 signaling pathway and inhibits the NF-κB signaling pathway to improve Alzheimer disease
Alzheimer disease (AD) is a common neurodegenerative disease with pathological features of accumulated amyloid plaques, neurofibrillary tangles, and...
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Phosphoinositides and intracellular calcium signaling: novel insights into phosphoinositides and calcium coupling as negative regulators of cellular signaling
Intracellular calcium (Ca 2+ ) and phosphoinositides (PIPs) are crucial for regulating cellular activities such as metabolism and cell survival. Cells...
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Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review
Cells within tissues are subject to various mechanical forces, including hydrostatic pressure, shear stress, compression, and tension. These...
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Purinergic Signaling in Brain Physiology
Since the discovery of purinergic signaling in the 1960s, many researchers focused on the central nervous system neurotransmission. Some neurons...
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Introduction to Cell Signaling Pathways and Brain Tumors
Cell signaling is the process by which cells coordinate and communicate with other cells, allowing cells to act in the correct way in response to...
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Purinergic Signaling in Parkinson’s Disease
Alterations in the brain basal ganglia compromise diverse neurological processes. The main symptoms are related to motor and mood control. The system...
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Neuron-Cancer Synaptic and Other Electrical Signaling
Cancers survive by recapitulating mechanisms of normal development. Neuronal activity has been well established as the master regulator of...
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Notch Cell Signaling Pathway and Brain Tumors
The Notch signaling pathway is highly conserved in most organisms (Artavanis-Tsakonas et al. 1999). There are four different types of Notch receptors...
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Androgen Receptor Signaling: A Central and Evolving Theme in Prostate Cancer Treatment
The biological function of the male hormones (androgens) is orchestrated through the activation of the androgen receptor-mediated signaling events...
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Wnt Signaling in Cancer
Stringent regulation of the Wnt pathways components and modulators is indispensable for the restoration of tissue homeostasis and development. The...