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Indomethacin Combined with Ciprofloxacin Improves the Prognosis of Mice under Severe Traumatic Infection via the PI3K/Akt Pathway in Macrophages
The prevention and treatment strategies for traumatic infection often focus on the use of antibiotics, while eschew the combined treatment of the...
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Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury
Pneumonia is a common comorbidity in patients with severe traumatic brain injury (TBI), and is associated with increased morbidity and mortality. In...
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Examining the impact of the COVID-19 pandemic on homecare services among individuals with traumatic and non-traumatic spinal cord injuries
Study designDescriptive repeated-cross sectional retrospective longitudinal cohort study.
ObjectiveTo investigate the impact of the COVID-19...
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Mild-to-severe traumatic brain injury in children: altered cytokines reflect severity
BackgroundPaediatric traumatic brain injury (TBI) is recognised to have significant longer-term neurocognitive effects. Childhood is a time of high...
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A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice
Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI...
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Blood virome of patients with traumatic sepsis
Sepsis is one of the possible outcomes of severe trauma, and it poses a dire threat to human life, particularly in immunocompromised people. The most...
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New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study
BackgroundTraumatic brain injury (TBI) has been reported as a risk factor for brain cancer development. However, the magnitude of the impact of TBI...
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Clinical Manifestations of Severe Scabies
Severe scabies, which includes crusted scabies, is an infectious ectoparasitic dermatosis with high mortality and is caused by a florid infestation...
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Clinical profile of COVID-19 infection among persons with spinal cord injury: a case series
Study designRetrospective case series.
ObjectiveTo report the clinical features and outcomes of spinal cord injury (SCI) patients with COVID-19 and...
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Traumatic Brain Injury
The most common traumatic brain injury type is mild form or concussion. This is especially a problem if these impacts happen frequently as in contact...
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Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury
The lectin pathway (LP) of complement mediates inflammatory processes linked to tissue damage and loss of function following traumatic brain injury...
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Cyclosporine as Therapy for Traumatic Brain Injury
Drug development in traumatic brain injury (TBI) has been impeded by the complexity and heterogeneity of the disease pathology, as well as limited...
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Pathogenesis of Post-Traumatic Stress Disorder and Therapeutic Targets
This review summarizes the current literature on the mechanisms of the pathogenesis of a severe stress-induced disorder – post-traumatic stress...
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Cerebrospinal Fluid as a Platform for Biomarker Identification in Traumatic Brain Injury
Traumatic brain injury (TBI) is a common cause for mortality and disability following severe head injury as well as milder concussive head injury....
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The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury
Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide, particularly among the elderly, yet our mechanistic...
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Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy
Subacute sclerosing panencephalitis (SSPE) occurs in some individuals after measles infection, following a symptom-free period of several years. It...
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Protective Effects of Plant-Derived Compounds Against Traumatic Brain Injury
Inflammation in the nervous system is one of the key features of many neurodegenerative diseases. It is increasingly being identified as a critical...
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Sleep Disturbances Among Patients with COVID-19 Infection
The COVID-19 pandemic had global implications for people’s physical and mental health. Sleep is one of the determinants of health and well-being and...
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RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury
Traumatic brain injury (TBI) is a global public safety issue that poses a threat to death, characterized by high fatality rates, severe injuries and...
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Post-traumatic Stress Disorder: Focus on Neuroinflammation
Post-traumatic stress disorder (PTSD), gaining increasing attention, is a multifaceted psychiatric disorder that occurs following a stressful or...
