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What’s the cut-point?: a systematic investigation of tau PET thresholding methods
BackgroundTau positron emission tomography (PET) is increasing in popularity for biomarker characterization of Alzheimer’s disease (AD), and recent...
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An Alternative Data Transformation Approach for ADA Cut Point Determination: Why Not Use a Weibull Transformation?
The testing of protein drug candidates for inducing the generation of anti-drug antibodies (ADA) plays a fundamental role in drug development. The...
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Validation of the Slovenian version of the Montreal Cognitive Assessment Scale as a screening tool for the detection of mild cognitive impairment
ObjectiveThe Montreal cognitive assessment scale (MoCA) is commonly used for detecting individuals with mild cognitive impairment (MCI). The aim of...
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Fatty Liver Index (FLI) is the best score to predict MASLD with 50% lower cut-off value in women than in men
BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is defined by the presence of hepatic steatosis, detected on...
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Comparison of Pre-existing Anti-AAV8 Total Antibody Screening and Confirmatory Assays with a Cell-Based Neutralizing Assay in Normal Human Serum
Pre-existing adeno-associated viruses (AAV) neutralizing antibodies (NAb) can prevent AAV vectors from transducing target tissues. The immune...
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Statistical Approaches for Establishing Appropriate Immunogenicity Assay Cut Points: Impact of Sample Distribution, Sample Size, and Outlier Removal
The statistical assessments needed to establish anti-drug antibody (ADA) assay cut points (CPs) can be challenging for bioanalytical scientists....
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Engineering Selective TIMPs Using a Counter-Selective Screening Strategy
The yeast surface display platform provides a powerful approach for screening protein diversity libraries to identify binders with an enhanced...
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A Novel Point-of-Care Rapid Diagnostic Test for Screening Individuals for Antibody Deficiencies
PurposeNo rapid diagnostic test exists to screen individuals for primary antibody deficiencies (PAD) at or near the point of care. In settings at...
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Molecular Dynamics as a Tool for Virtual Ligand Screening
Rational drug design is essential for new drugs to emerge, especially when the structure of a target protein or nucleic acid is known. To that...
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Clinical Validation of a Primary Antibody Deficiency Screening Algorithm for Primary Care
PurposeThe diagnostic delay of primary antibody deficiencies (PADs) is associated with increased morbidity, mortality, and healthcare costs....
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Validation of the Asia-Pacific colorectal screening score and its modified versions in predicting colorectal advanced neoplasia in Chinese population
BackgroundColorectal cancer is one of the most common cancers in the world. Several studies suggest using the Asia-Pacific colorectal screening...
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Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer
Human papillomavirus can cause preinvasive, high-grade squamous intraepithelial lesions (HSILs) as precursors to cancer in the anogenital area, and...
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Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
BackgroundHereditary factors, including single genetic variants and family history, can be used for targeting colorectal cancer (CRC) screening, but...
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CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy
Target cancer therapy has been developed for clinical cancer treatment based on the discovery of CRISPR (clustered regularly interspaced short...
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Development and validation of new screening tool for predicting dementia risk in community-dwelling older Japanese adults
BackgroundEstablished clinical assessments for detecting dementia risk often require time, cost, and face-to-face meetings. We aimed to develop a...
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Consanguinity and willingness to perform premarital genetic screening in Sudan
Consanguineous marriage is prevalent in certain world regions due to cultural, economic, and social reasons. However, it can lead to negative...
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Screening for prostate cancer in a city in Japan: age-specific prostate-specific antigen cutoff thresholds
PurposeOlder men have higher prostate-specific antigen levels than younger men. However, the current Japanese Urological Association guidelines...
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Newborn Screening for Severe T and B Cell Lymphopenia Using TREC/KREC Detection: A Large-Scale Pilot Study of 202,908 Newborns
Newborn screening (NBS) for severe inborn errors of immunity (IEI), affecting T lymphocytes, and implementing measurements of T cell receptor...
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Harmonization of ANA testing challenge: quantification strategy to accurately predict end-point titers avoiding serial dilution
Despite the advantages of automated systems for antinuclear antibody (ANA) analysis, the prediction of end-point titers avoiding serial dilutions is...
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Investigating the role of county-level colorectal cancer screening rates on stage at diagnosis of colorectal cancer in rural Georgia
BackgroundTo examine the impact of county-level colorectal cancer (CRC) screening rates on stage at diagnosis of CRC and identify factors associated...