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Predictors of relapse severity in multiple sclerosis
BackgroundThe severity of relapses is one of the determinants of residual disability in multiple sclerosis (MS), contributing to the final...
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Individual differences in cocaine seeking during voluntary abstinence predicts cocaine relapse and the circuitry mediating relapse
RationaleThere are no FDA-approved treatments to facilitate recovery from cocaine use disorder. Contingency management offers non-drug reinforcers to...
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Comprehensive insights into AML relapse: genetic mutations, clonal evolution, and clinical outcomes
IntroductionAcute myeloid leukemia (AML) is a complex hematologic malignancy characterized by uncontrolled proliferation of myeloid precursor cells...
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Helper T cell bias following tuberculosis chemotherapy identifies opportunities for therapeutic vaccination to prevent relapse
Therapeutic vaccines have promise as adjunctive treatment for tuberculosis (TB) or as preventives against TB relapse. An important development...
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Proteomics to predict relapse in patients with myelodysplastic neoplasms undergoing allogeneic hematopoietic cell transplantation
Disease relapse remains a major barrier to success after allogeneic hematopoietic cell transplantation (allo-HCT) in myelodysplastic neoplasms (MDS)....
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Hepatitis B relapse after entecavir or tenofovir alafenamide cessation under anti-viral prophylaxis for cancer chemotherapy
BackgroundNo study has comparing hepatitis B virus (HBV) relapse rates among patients with both cancer and hepatitis B e antigen (HBeAg)-negative...
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Time to relapse in chronic lymphocytic leukemia and DNA-methylation-based biological age
Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with a predilection for older individuals. While previous studies have identified...
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The Role of Cytogenetic Rearrangements in the Formation of Resistance in Relapse of Acute Lymphoblastic Leukemia
AbstractCytogenetic rearrangements were studied in bone marrow cells of 24 patients with relapse of acute lymphoblastic leukemia (ALL). The authors...
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Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence
Alcohol dependence is a disorder with a high recurrence rate that leads to a considerable public health burden. The risk of relapse appears to be...
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Learning processes in relapse to alcohol use: lessons from animal models
RationaleAlcohol use is reliably preceded by discrete and contextual stimuli which, through diverse learning processes, acquire the capacity to...
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Identifying breast cancer patients at risk of relapse despite pathological complete response after neoadjuvant therapy
This retrospective pooled analysis aims to identify factors predicting relapse despite a pathologic complete response (pCR) in patients with breast...
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Regulator of G protein signaling 6 (RGS6) in dopamine neurons promotes EtOH seeking, behavioral reward, and susceptibility to relapse
Mesolimbic dopamine (DA) transmission is believed to play a critical role in mediating reward responses to drugs of abuse, including alcohol (EtOH)....
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Preclinical Models of Relapse to Psychostimulants Induced by Environmental Stimuli
A major aim of addiction research is the understanding of the pathophysiological profile of relapse risk and the development of treatments for...
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Relapse after CAR-T cell therapy in B-cell malignancies: challenges and future approaches
Chimeric antigen receptor-T (CAR-T) cell therapy, as a novel cellular immunotherapy, has dramatically reshaped the landscape of cancer treatment,...
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Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: immune escape mechanisms and current implications for therapy
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the expansion of immature myeloid cells in the bone marrow (BM) and...
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Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues
RationaleWhen people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include...
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Analysis of the relapse of imported Plasmodium vivax and Plasmodium ovale in five provinces of China
BackgroundThe global battle against malaria is facing formidable challenges, particularly in controlling Plasmodium vivax and Plasmodium ovale ,...
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The role of the genomic mutation signature and tumor mutation burden on relapse risk prediction in head and neck squamous cell carcinoma after concurrent chemoradiotherapy
Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and...
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Early relapse is an adverse prognostic factor for survival outcomes in patients with oral cavity squamous cell carcinoma: results from a nationwide registry study
BackgroundThe prognostic significance of the relapse interval in patients with resected oral cavity squamous cell carcinoma (OCSCC) is a matter of...
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Measurable residual disease monitoring by ddPCR in the early posttransplant period complements the traditional MFC method to predict relapse after HSCT in AML/MDS: a multicenter retrospective study
BackgroundDroplet digital PCR (ddPCR) is widely applied to monitor measurable residual disease (MRD). However, there are limited studies on the...
