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Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases
Plants and their derived phytochemicals have a long history of treating a wide range of illnesses for several decades. They are believed to be the...
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The beneficial health effects of puerarin in the treatment of cardiovascular diseases: from mechanisms to therapeutics
Cardiovascular diseases (CVDs) are the leading causes of death globally that seriously threaten human health. Although novel western medicines have...
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Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics
Network pharmacology and bioinformatics were used to study puerarin’s molecular mechanism in treating osteoarthritis from the perspective of...
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Puerarin-V prevents the progression of hypoxia- and monocrotaline-induced pulmonary hypertension in rodent models
Pulmonary hypertension (PH) is a cardiopulmonary disease characterized by a progressive increase in pulmonary vascular resistance. One of the initial...
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Metal-polyphenol microgels for oral delivery of puerarin to alleviate the onset of diabetes
Puerarin (Pue) is a naturally bioactive compound with many potential functions in regulating blood glucose and lipid metabolism. However, the low...
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Puerarin Loaded PLGA Nanoparticles: Optimization Processes of Preparation and Anti-alcohol Intoxication Effects in Mice
To improve the bioavailability of puerarin in liver, the optimized preparation method of puerarin-PLGA nanoparticles (Pue-PLGA-nps) and the effect of...
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Puerarin protects cardiomyocytes from ischemia–reperfusion injury by upregulating LncRNA ANRIL and inhibiting autophagy
This study analyzed the roles of puerarin and LncRNA ANRIL in myocardial ischemia–reperfusion injury. Hypoxia/reperfusion (H/R) model was established...
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Puerarin reduces impairment of intestinal and adipose immune responses to influenza virus infection in mice
Influenza is an acute viral respiratory disease that can also cause gastroenteritis-like symptoms, such as abdominal pain, nausea, vomiting, and...
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In Vitro Approach and Quantification of “Puerarin and Genistein”: Valuable Antidiabetic Compounds from Pueraria tuberosa
To produce elite clones of plants, in vitro approach is most acceptable. Plants with susceptible germination rates and dependency on a specific plant...
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Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway
Estrogen deficiency induces cardiac dysfunction and increases the risk of cardiovascular disease in postmenopausal women and in those who underwent...
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Mechanistic analyses reveal that Pueraria montana var. lobata (Willd.) is effective in inhibiting ovarian cancer progression
Ovarian cancer (OC) is a common malignancies of the female genitalia. P. montana var . lobata (Willd.), a herb with anti-tumor effects, is widely used...
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Fabrication of Fine Puerarin Nanocrystals by Box–Behnken Design to Enhance Intestinal Absorption
Puerarin is widely used as a therapeutic agent to cardiovascular diseases in clinics in China through intravenous administration, which could elicit...
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Puerarin Alleviates Lipopolysaccharide-Induced Myocardial Fibrosis by Inhibiting PARP-1 to Prevent HMGB1-Mediated TLR4-NF-κB Signaling Pathway
Myocardial fibrosis (MFs) is a crucial pathological process that results in cardiac failure in the development of multiple cardiovascular diseases....
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Thermal Extrusion 3D Printing for the Fabrication of Puerarin Immediate-Release Tablets
Thermal extrusion (TE) 3D printing is a thermoplastic semisolid-based rapid prototy** process, which is capable of building complex structures. The...
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Beneficial effects of flavonoids on cardiovascular diseases by influencing NLRP3 inflammasome
Cardiovascular diseases (CVDs) are a leading cause of global mortality and have a high incidence rate worldwide. The function of inflammasomes in...
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Correction to: Puerarin alleviates burn-related procedural pain mediated by P2X3 receptors
Due to the authors’ carelessness, we used mistakenly PBMCs isolated from same patient in Fig. 1a for P2X3 immunoreactivity in VI: PUE-treated group...
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Puerarin Protects Against LPS-Induced Vascular Endothelial Cell Hyperpermeability via Preventing Downregulation of Endothelial Cadherin
In the present study, we aimed to investigate the effects of puerarin on the hyperpermeability of vascular endothelial cells induced by...
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Flexibility of 3D Extruded Printing for a Novel Controlled-Release Puerarin Gastric Floating Tablet: Design of Internal Structure
The objective of this study was to investigate the development of a novel puerarin gastric floating system with a concentric annular internal pattern...
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Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer’s disease: flavonoids and phenols
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloid plaques and tangles that have become the fifth leading cause of...
