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Research progress on pharmacological effects and bioavailability of berberine
Berberine (BBR), a benzylisoquinoline alkaloid obtained from natural medicines such as coptidis rhizoma , has a wide range of pharmacological...
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Altitude Acclimatization Via Pharmacological and Non-pharmacological Interventions
The key element of hypobaric hypoxia is declined barometric pressure and lower partial pressure at high altitudes. Hypobaric hypoxia at high...
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Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives
Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid compound found in plants of the Stephania genus, which has biological functions such as...
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Effects of Pharmacological Treatments in Alzheimer’s Disease: Permutation Entropy-Based EEG Complexity Study
Alzheimer’s disease (AD) is a neurodegenerative brain disease affecting cognitive and physical functioning. The currently available pharmacological...
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Effects of Pharmacological Agents on CSD
The involvement of various drugs and pharmacological agents in the event named CSD is the subject of the current chapter. The advantage of using the...
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Sleep deprivation induces late deleterious effects in a pharmacological model of Parkinsonism
Parkinson’s disease is a degenerative, chronic and progressive disease, characterized by motor dysfunctions. Patients also exhibit non-motor...
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Quantification of Unencapsulated Drug in Target Tissues Demonstrates Pharmacological Properties and Therapeutic Effects of Liposomal Topotecan (FF-10850)
PurposeQuantifying unencapsulated drug concentrations in tissues is crucial for understanding the mechanisms underlying the efficacy and safety of...
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Gastrodin: a comprehensive pharmacological review
Tianma is the dried tuber of Gastrodia elata Blume ( G. elata ), which is frequently utilized in clinical practice as a traditional Chinese medicine....
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Functions and targets of miRNAs in pharmacological and toxicological effects of major components of Tripterygium wilfordii Hook F
Tripterygium wilfordii Hook F (TwHF) has a long history of use as a traditional Chinese medicine and has been widely administered to treat various...
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Pharmacological update of mirtazapine: a narrative literature review
Mirtazapine (MTZ) is an antidepressant drug with an exceptional pharmacological profile. It also has an excellent safety and tolerability profile....
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Effects of Pharmacological Intervention on Recovery After Sevoflurane Anesthesia in Children: a Network Meta-analysis of Randomized Controlled Trials
Sevoflurane, commonly administered to children as anesthesia, often leads to emergence delirium (ED). Currently, a consensus is lacking among...
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Pharmacological evidence for glutamatergic pathway involvement in the antidepressant-like effects of 2-phenyl-3-(phenylselanyl)benzofuran in male Swiss mice
Depression is a multifactorial and heterogeneous disease with several neurobiological mechanisms underlying its pathophysiology, including...
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Pharmacological Effects of a New Soluble Guanylate Cyclase Stimulator in Experimental Ischemic Stroke
We studied the action of a new indolinone derivative GRS, acetylsalicylic acid (ASA), and their combination on platelet aggregation, vasodilatory...
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Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice
Acquisition and extinction of associative fear memories are critical for guiding adaptive behavioral responses to environmental threats, and...
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A comprehensive review on Schisandrin and its pharmacological features
Schisandrin stands as one of the primary active compounds within the widely used traditional medicinal plant Schisandra chinensis (Turcz.) Baill....
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Clinical Pharmacological Considerations in Transgender Medicine
Transgender medicine is a growing clinical field. Hormone therapy (testosterone or estrogen treatment) is part of the standard of gender-affirming...
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Pharmacological Modulation of the Cytosolic Oscillator Affects Glioblastoma Cell Biology
The circadian system is a conserved time-kee** machinery that regulates a wide range of processes such as sleep/wake, feeding/fasting, and...
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Auditory brainstem responses are resistant to pharmacological modulation in Sprague Dawley wild-type and Neurexin1α knockout rats
Sensory processing in the auditory brainstem can be studied with auditory brainstem responses (ABRs) across species. There is, however, a limited...
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Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats
RationaleMotivational dysfunctions related to effort exertion are common in psychiatric disorders. Dopamine systems regulate exertion of effort and...
