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In Vitro Patch-Clamp
The patch-clamp technique is one of the most useful tools to analyze the function of electrically active cells such as neurons. This technique allows...
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Whole Cell Patch Clamp Electrophysiology in Human Neuronal Cells
Whole cell patch clamp recording techniques are commonly used to assay membrane excitability, ion channel function, and synaptic activity in neurons....
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Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2
BackgroundSARS-CoV-2 has caused a worldwide pandemic since December 2019 and the search for pharmaceutical targets against COVID-19 remains an...
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Patch Clamp Electrophysiology Methods and Protocols
This volume describes a range of standard and novel methodological approaches used to probe ion channel function across different modalities....
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Patch Clamp Technology for Focused Ultrasonic (FUS) Neuromodulation
Electrical stimulation of neural tissue, such as deep brain stimulation (DBS) and cortical stimulation, is widely applied therapeutic neuromodulation...
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Patch-Clamp Electrophysiological Analysis of Murine Melanopsin Neurons
Intrinsically photosensitive retinal ganglion cells (ipRGCs) regulate diverse aspects of mammalian physiology, including the synchronization of...
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In Vivo Patch-Clamp Studies
Intact and functioning brain enables quantification of neural activities directly associated with real world such as visual and auditory information....
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An Introduction to Patch Clamp Recording
Electrophysiology is an essential tool aiding the study of the functions and dysfunctions of electrically excitable cells and their networks. The...
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Estimating the Ca2+ Permeability of NMDA Receptors with Whole-Cell Patch-Clamp Electrophysiology
In the mammalian central nervous system (CNS), fast excitatory transmission relies primarily on the ionic fluxes generated by ionotropic glutamate...
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Patch Clamp Technology in the Twenty-First Century
In the almost four decades since its inception, the patch clamp technique has transitioned from a specialist skill to a method commonly used among...
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Patch Clamp: The First Four Decades of a Technique That Revolutionized Electrophysiology and Beyond
Forty years ago, the introduction of a new electrophysiological technique, the patch clamp, revolutionized the fields of Cellular Physiology and...
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Strategies for Identification of Medial Olivocochlear Neurons for Patch-Clamp Studies of Synaptic Function Using Electrical Stimulation and Optogenetics
To understand how action potential patterns are generated in a single neuron, analysis of intrinsic electrical properties and the integration of...
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Perforated Whole-Cell Recordings in Automated Patch Clamp Electrophysiology
The automated patch clamp (APC) technology is used for increasing the data throughput of electrophysiological measurements, especially in safety...
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Combining Whole-Cell Patch-Clamp Recordings with Single-Cell RNA Sequencing
To understand how the brain functions we need to understand the properties of its constituent cells. Whole-cell patch-clamp recordings of neurons...
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Advancing Ion Channel Research with Automated Patch Clamp (APC) Electrophysiology Platforms
Since its development on the cusp of the new millennium, automated patch clamp (APC) technology has matured over the last two decades. The increased...
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Single or Double Patch-Clamp Recordings In Ex Vivo Slice Preparation: Functional Connectivity, Synapse Dynamics, and Optogenetics
Patch-clamp recordings are the method of choice to define cell-type specific electrophysiological properties of single neurons and the synaptic...
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Patch-Clamp Recording of the Activity of Ion Channels in the Inner Mitochondrial Membrane
Mitochondria are intracellular organelles, which play a crucial role in the generation of ATP. Mitochondria are surrounded by a double membrane,...
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Electrophysiological Methods to Measure Ca2+ Current
To achieve the most accurate assessment of functional Ca2+ channel or modulator properties and their regulation, a patch-clamp technique to record...
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Electrophysiological Recordings of Oligodendroglia in Adult Mouse Brain Slices
Communication between neurons and oligodendrocyte lineage cells has attracted a great interest since multiple discoveries revealed its important...