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Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer
Dysregulated G protein-coupled receptor signaling is involved in the formation and progression of human cancers. The heterotrimeric G protein Gα 13 is...
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Entosis: the core mechanism and crosstalk with other cell death programs
Cell death pathways play critical roles in organism development and homeostasis as well as in the pathogenesis of various diseases. While studies...
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Biology, Chemistry, and Physics of Cancer Cell Motility and Metastasis
A malignant tumor has ability to invade the nearby tissues and colonize distant sites (organs) through the lymphatic/vascular system. From...
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Molecular-Genetic Bases of Mammary Gland Development Using the Example of Cattle and Other Animal Species: I. Embryonic and Pubertal Developmental Stage
AbstractThe growing demand of society for the products of farm animals entails continuous modernization of breeding programs. In order to improve the...
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CD147 promotes cell motility via upregulation of p190-B RhoGAP in hepatocellular carcinoma
BackgroundThe acquisition of inappropriate migratory feature is crucial for tumor metastasis. Rho-family GTPases including RhoA are molecular...
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Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation
Endothelial barrier disruption and vascular leak importantly contribute to organ dysfunction and mortality during inflammatory conditions like sepsis...
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Role of estrogen receptors and Src signaling in mechanisms of bone metastasis by estrogen receptor positive breast cancers
Background/aimEvidence shows that Luminal A breast cancer is likely to undergo bone metastasis, but the mechanisms involved remain unknown. This...
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Cytoskeletal Signal-Regulated Oligodendrocyte Myelination and Remyelination
Myelination and remyelination in the central nervous system (CNS) are essential for rapid conduction of action potentials and for appropriate...
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Cell-in-cell phenomena in cancer
Cell-in-cell structures are reported in numerous cancers, and their presence is an indicator for poor prognosis. Mechanistic studies have identified...
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FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression
BackgroundGenome-wide association studies (GWASs) have shown that genetic variants are important determinants of free fatty acid levels. The...
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Isometric Retraction and Invisible Nerve Cell Processes
Many physiological studies in recent years on stress and hibernation have noted an unusual morphological phenomenon consisting of the rapid...
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Semaphorin Receptors and Their Signaling
Semaphorins, which are a large family of secreted and membrane-bound molecules, were initially identified as neuronal axon-guidance signaling...
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Preoptic Regulatory Factor-2, a Rhogap Domain Protein that Modifies Cell Cycle Progression and Apoptosis in the CNS
RhoGAPS are proteins that control Rho GTPases, small enzymes that regulate diverse cellular functions. Preoptic regulatory factor-2 (Porf-2) is a...
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The Darwinian Dynamics of Motility and Metastasis
Cancer is a deadly disease, but it is rarely the primary tumor that kills patients. Most cancer deaths are due to metastasis, a complex and still...