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Combination of mesenchymal stromal cells and machine perfusion is a novel strategy for organ preservation in solid organ transplantation
Organ preservation is a prerequisite for an urgent increase in the availability of organs for solid organ transplantation (SOT). An increasing amount...
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High dose chemoradiotherapy increases chance of organ preservation with satisfactory functional outcome for rectal cancer
BackgroundHigh dose chemoradiotherapy offers a curative chance for patients with rectal cancer that are unfit or unwilling to undergo surgical...
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Thyroid hormone protects human lung epithelial cells from cold preservation and warm reperfusion-induced injury
BackgroundCellular stress associated with static-cold storage (SCS) and warm reperfusion of donor lungs can contribute to ischemia–reperfusion (IR)...
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Development and Characterization of a Nonelectronic Versatile Oxygenating Perfusion System for Tissue Preservation
Oxygenated machine perfusion of human organs has been shown to improve both preservation quality and time duration when compared to the current gold...
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Monoclonal Antibodies in Solid Organ Transplantation
In an attempt to target solid organ transplant immunosuppression, monoclonal antibodies directed against key steps in specific immunologic pathways...
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Model-Guided Design and Optimization of CPA Perfusion Protocols for Whole Organ Cryopreservation
Vitrification could enable long-term organ preservation, but only after loading high-concentration, potentially toxic cryoprotective agents (CPAs) by...
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Anus preservation in low rectal adenocarcinoma based on MMR/MSI status (APRAM): a study protocol for a randomised, controlled, open-label, multicentre phase III trial
BackgroundAnus preservation has been a challenge in the treatment of patients with low rectal adenocarcinoma (within 5 cm from the anal verge)...
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Organ Toxicity by Immunosuppressive Drugs in Solid Organ Transplantation
Solid organ transplantation is the preferred therapeutic option that confers significant survival advantage on patients suffering from end-organ...
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Immune response associated with ischemia and reperfusion injury during organ transplantation
BackgroundIschemia and reperfusion injury (IRI) is an ineluctable immune-related pathophysiological process during organ transplantation, which not...
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Organ, Histotypic and Organotypic Culture, and Tissue Engineering
Organ, histotypic, and organotypic culture using mammalian three-dimensional (3D) cell culture technologies are the primary focus of this chapter....
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Immunometabolism and Organ Transplantation
Inflammation fundamentally influences short and long-term performance of solid organ allografts. Thus, it is relevant to control inflammatory...
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The Interplay of the Renin-Angiotensin System and Solid Organ Transplantation
The renin-angiotensin system (RAS) plays a powerful role in controlling sodium balances, fluid body volumes, and arterial pressures. New studies...
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Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage
The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising...
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Advanced technologies for the preservation of mammalian biospecimens
The three classical core technologies for the preservation of live mammalian biospecimens—slow freezing, vitrification and hypothermic storage—limit...
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The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications
Fibrosis-related disorders account for an enormous burden of disease-associated morbidity and mortality worldwide. Fibrosis is defined by excessive...
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Delivery of Therapeutics to Solid Organs Using Ex Vivo Machine Perfusion
The use of ex vivo machine perfusion for organ preservation has significantly improved solid organ transplantation outcomes. This modality of organ...
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A multi-centre randomized controlled trial investigating Consolidation Chemotherapy with and without oxaliplatin in distal rectal cancer and Watch & Wait
BackgroundNeoadjuvant chemoradiation(nCRT) has been considered the preferred initial treatment strategy for distal rectal cancer. Advantages of this...
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Transperineal Targeted Microwave Ablation (TMA) of localized prostate cancer guided by MRI-Ultrasound fusion and organ-based tracking: a pilot study
BackgroundTo investigate the efficacy of transperineal targeted microwave ablation (TMA) in treating localized prostate cancer (PCa).
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Organ-on-a-Chip: Novel In Vitro Model for Drug Discovery
In conventional drug discovery process, the attrition in clinical development as a consequence of late clinical trial failure has been very high. One...