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Enhanced Oral Bioavailability of Isoformononetin Through Nanoemulsion: Development, Optimization, and Characterization
BackgroundIsoformononetin (IFN) is a methoxyl derivative of daidzein and has been stated as a potent osteogenic isoflavone. However, IFN has low oral...
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Water in nigella oil microemulsion for enhanced oral bioavailability of linagliptin
Linagliptin is hydrophilic antidiabetic with poor oral bioavailability due to poor permeability and pre-systemic metabolism. The objective was to...
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Enhanced Oral Bioavailability of Progesterone in Bilosome Formulation: Fabrication, Statistical Optimization, and Pharmacokinetic Study
Progesterone, a female sex steroid hormone, is highly lipophilic, leading to poor oral bioavailability. This study aimed to develop a progesterone...
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Bioavailability and Bioequivalence
Bioavailability and bioequivalence assessments of formulations are components of the marketing authorization/approval process for drug products. New...
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A Quality by Design Approach for Develo** SNEDDS Loaded with Vemurafenib for Enhanced Oral Bioavailability
Vemurafenib (VMF) is a practically insoluble (< 0.1 μg/mL) and least bioavailable (1%) drug. To enhance its oral bioavailability and solubility, we...
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A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice
Butyrate—a metabolite produced by commensal bacteria—has been extensively studied for its immunomodulatory effects on immune cells, including...
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SNAC for Enhanced Oral Bioavailability: An Updated Review
The delivery of proteins and peptides via an oral route poses numerous challenges to improve the oral bioavailability and patient compliance. To...
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Novel rivaroxaban-loaded microsphere systems with different surface microstructure for enhanced oral bioavailability
This study compares rivaroxaban-loaded polymeric microsphere systems with three types of surface microstructure. Three types of polymeric...
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Simple preparation and greatly improved oral bioavailability: The supersaturated drug delivery system of quercetin based on PVP K30
Quercetin, as a representative flavonoid, is widely present in daily diet and has been developed as a dietary supplement due to its beneficial...
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Evaluation of microstructure, dissolution rate, and oral bioavailability of paclitaxel poloxamer 188 solid dispersion
Poor solubility is a major challenge for enhancing the oral bioavailability and clinical application of many drugs, including the broad-spectrum...
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Core Shell Lipid-Polymer Hybrid Nanoparticles for Oral Bioavailability Enhancement of Ibrutinib via Lymphatic Uptake
The purpose of this research was to develop ibrutinib (IBR)-loaded lipid-polymer hybrid nanoparticles (IBR-LPHNPs) to improve oral absorption by...
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Preparation, characterization, oral bioavailability, and pharmacodynamic study of eugenol-porous silica solidified powder
Eugenol possesses anti-inflammatory and antioxidant properties, and may serve as a potential therapeutic agent for hepatic fibrosis. However, the...
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Orodispersible film incorporating nanoparticulate loratadine for an enhanced oral bioavailability
PurposeLoratadine (LOR), a commonly prescribed antihistamine, has low water solubility but high permeability. In this study, an orodispersible film...
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Multi-functional Chitosan Polymeric Micelles for improving the oral bioavailability of Paclitaxel based on synergistic effect
A novel multi-functional micelle delivery system was developed for enhancing the oral absorption of paclitaxel (PTX). The delivery carriers were...
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Development of abiraterone acetate tablets with enhanced oral bioavailability
PurposeAbiraterone acetate (ABA), a precursor drug inhibiting androgen biosynthesis (CYP17 inhibitor), is used for treating metastatic...
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Oral Bioavailability Enhancement of Docetaxel by Preparation of Freeze-Dried Ternary Solid Dispersion Using Hydrophilic Polymer and Surfactant
PurposeThe poor solubility and permeability of docetaxel have limited its oral delivery. The current study was aimed at formulating the ternary solid...
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Oral bioavailability of microdoses and therapeutic doses of midazolam as a 2-dimensionally printed orodispersible film in healthy volunteers
PurposeThe use of two-dimensional (2D) printing technologies of drugs on orodispersible films (ODF) can promote dose individualization and facilitate...
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Processability and Oral Bioavailability Improvement of Itraconazole by Particle Engineering Technique
The current study aimed to improve the processability and oral bioavailability of itraconazole (ITZ) via spherical agglomeration. ITZ-spherical...
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The Effect of Inflammatory Bowel Disease and Irritable Bowel Syndrome on Pravastatin Oral Bioavailability: In vivo and in silico evaluation using bottom-up wbPBPK modeling
The common disorders irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) can modify the drugs' pharmacokinetics via their induced...
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Improving in vivo oral bioavailability of a poorly soluble drug: a case study on polymeric versus lipid nanoparticles
Poorly soluble drugs must be appropriately formulated for clinical use to increase the solubility, dissolution rate, and permeation across the...
