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Usefulness of daptomycin lock therapy in children with catheter-related bacteremia after failed vancomycin lock therapy
PurposeCatheter-related bacteremia (CRB) is a significant cause of morbidity, resource expenditure and prolonged hospital stays in patients with...
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The Role of Cytogenetic Rearrangements in the Formation of Resistance in Relapse of Acute Lymphoblastic Leukemia
AbstractCytogenetic rearrangements were studied in bone marrow cells of 24 patients with relapse of acute lymphoblastic leukemia (ALL). The authors...
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Implementation of Chromatic Super CAZ/AVI® medium for active surveillance of ceftazidime-avibactam resistance: preventing the loop from becoming a spiral
Acquired resistance towards ceftazidime-avibactam (CAZ-AVI) is increasingly reported. Several mechanisms can be involved, but mutations in the Ω-loop...
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Impact of Early Access Reform on Oncology Innovation in France: Approvals, Patients, and Costs
BackgroundAn ambitious reform of the early access (EA) process was set up in July 2021 in France, aiming to simplify procedures and accelerate access...
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Morphofunctional Features of Hematopoietic Bone Marrow Progenitor Cells in Patients with Chronic Myeloid Leukemia in Long-Term Culture of Gel Diffusion Chambers In Vivo
AbstractThe search for ways to support the long-term cultivation of hematopoietic stem cells, their expansion, and studies of long-term growth...
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Immune tumoral microenvironment in gliomas: focus on CD3+ T cells, Vδ1+ T cells, and microglia/macrophages
Gliomas are histologically defined as low-grade gliomas (LGG) and high-grade gliomas (HGG). The most common type of HGG is the glioblastoma (GBM). We...
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Osteogenic Commitment of MSC Is Enhanced after Interaction with Umbilical Cord Blood Mononuclear Cells In Vitro
The effectiveness of stroma-dependent expansion of hematopoietic cells ex vivo may depend on the level of commitment of multipotent mesenchymal...
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Immune Gene Therapy of Cancer
Cancer is the second global cause of mortality. Conventional treatments, such as chemotherapy and radiotherapy, have not provided desirable...
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Large-Scale Postmarketing Surveillance of Biological Drugs for Immune-Mediated Inflammatory Diseases Through an Italian Distributed Multi-Database Healthcare Network: The VALORE Project
BackgroundBiological drugs have improved the management of immune-mediated inflammatory diseases (IMIDs) despite being associated with important...
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Cancer Genomics in Precision Oncology: Applications, Challenges, and Prospects
Precision medicine has evolved in the last decade following advances in molecular biology technology. The completion of the Human Genome Project...
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Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients
BackgroundGenetically engineered chimeric antigen receptor (CAR) T lymphocytes are promising therapeutic tools for cancer. Four CAR T cell drugs,...
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Chagas Disease in Immunosuppressed Patients
This chapter is a brief update on immunosuppression and Chagas disease (CD) and refers to the pharmacological immunosuppression in solid organ...
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FISH and chips: a review of microfluidic platforms for FISH analysis
Fluorescence in situ hybridization (FISH) allows visualization of specific nucleic acid sequences within an intact cell or a tissue section. It is...
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Monocytes with Oncogenic Mutation JAK2 V617F as a Tool for Studies of the Pathogenic Mechanisms of Myelofibrosis
We analyzed previously generated stable monocyte-derived cell line carrying mutation JAK2 V617F . Evaluation of the expression of pro- and...
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Cost of cancer diagnosis using next-generation sequencing targeted gene panels in routine practice: a nationwide French study
It is currently unclear if next-generation sequencing (NGS) technologies can be implemented in the diagnosis setting at an affordable cost. The aim...
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Anagrelide and Mutational Status in Essential Thrombocythemia
BackgroundAnagrelide is an orally active, quinazolone-derived, platelet-lowering agent that acts by blocking megakaryocyte maturation and...
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Acute myeloid leukemia and pregnancy: clinical experience from a single center and a review of the literature
BackgroundAcute myeloid leukemia (AML) accounts for more than two thirds of leukemia during pregnancy and has an incidence of 1 in 75,000 to 100,000....
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Incidence of Myelofibrosis in Chronic Myeloid Leukemia, Multiple Myeloma, and Chronic Lymphoid Leukemia during Various Phases of Diseases
Pathomorphological study of trephinobiopsy specimens from 129 patients with lymphoproliferative and myeloproliferative diseases was carried out over...
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Cytogenetic and molecular cytogenetic investigations in relapse of B-cell chronic lymphocytic leukemia
Сhromosomal abnormalities have been analyzed in bone marrow cells of 61 patients with relapse of B-cell chronic lymphocytic leukemia. The cytogenetic...
