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Recombinant lipidated FLIPr effectively enhances mucosal and systemic immune responses for various vaccine types
Formyl peptide receptor-like 1 inhibitor protein (FLIPr) is an immune evasion protein produced by Staphylococcus aureus , and FLIPr is a potential...
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Mucosal Exposome and Intestinal Carcinogenesis
Mucosal exposomes are the internal frontline of defense against xenobiotics, pathogens, and microbiota. The mucosal network of human immunity is...
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Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Mucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the...
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CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system
The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid...
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Establishment of isotype-switched, antigen-specific B cells in multiple mucosal tissues using non-mucosal immunization
Although most pathogens infect the human body via mucosal surfaces, very few injectable vaccines can specifically target immune cells to these...
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Versatile roles of innate lymphoid cells at the mucosal barrier: from homeostasis to pathological inflammation
Innate lymphoid cells (ILCs) are innate lymphocytes that do not express antigen-specific receptors and largely reside and self-renew in mucosal...
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An intranasal combination vaccine induces systemic and mucosal immunity against COVID-19 and influenza
Despite prolonged surveillance and interventions, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses continue to...
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Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance
BackgroundGamma-delta (γδ) T cells are a major cell population in the intestinal mucosa and are key mediators of mucosal tolerance and microbiota...
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The P2X7 receptor in mucosal adaptive immunity
The P2X7 receptor (P2X7R) is a widely distributed cation channel activated by extracellular ATP (eATP) with exclusive peculiarities with respect to...
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Multicomponent intranasal adjuvant for mucosal and durable systemic SARS-CoV-2 immunity in young and aged mice
Multiple FDA-approved SARS-CoV-2 vaccines currently provide excellent protection against severe disease. Despite this, immunity can wane relatively...
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Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers
Alzheimer’s disease (AD) and related tauopathies are associated with pathological tau protein aggregation, which plays an important role in...
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Double-edged sword: γδ T cells in mucosal homeostasis and disease
The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in...
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Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines
The development and deployment of vaccines against COVID-19 demonstrated major successes in providing immunity and preventing severe disease and...
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Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection
Coordinated local mucosal and systemic immune responses following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either...
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Mucosal bivalent live attenuated vaccine protects against human metapneumovirus and respiratory syncytial virus in mice
Live-Attenuated Vaccines (LAVs) stimulate robust mucosal and cellular responses and have the potential to protect against Respiratory Syncytial Virus...
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Nanotechnology of inhalable vaccines for enhancing mucosal immunity
Vaccines are the cornerstone of world health. The majority of vaccines are formulated as injectable products, facing the drawbacks of cold chain...
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Polyanhydride nanovaccine against H3N2 influenza A virus generates mucosal resident and systemic immunity promoting protection
Influenza A virus (IAV) causes significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics. The antigenic...
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Short-term dietary changes can result in mucosal and systemic immune depression
Omnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich in fat over plant-based diets, especially for short periods...
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Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response
The key role of structural cells in immune modulation has been revealed with the advent of single-cell multiomics, but the underlying mechanism...
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Vaccination with recombinant Lactococcus lactis expressing HA1-IgY Fc fusion protein provides protective mucosal immunity against H9N2 avian influenza virus in chickens
BackgroundH9N2 virus is mainly transmitted through the respiratory mucosal pathway, so mucosal immunity is considered to play a good role in...
