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Brain metastases in Japanese NSCLC patients: prognostic assessment and the use of osimertinib and immune checkpoint inhibitors—retrospective study
BackgroundThe Graded Prognostic Assessment for lung cancer using molecular markers (Lung-molGPA) has not been validated for use with Japanese...
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Effect of brain radiotherapy strategies on prognosis of patients with EGFR-mutant lung adenocarcinoma with brain metastasis
PurposeEpidermal growth factor receptor ( EGFR )-mutant lung cancers have a high risk of develo** brain metastases (BM). Whole brain radiotherapy...
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Development and adaptations of the Graded Prognostic Assessment (GPA) scale: a systematic review
The Graded Prognostic Assessment (GPA) score has the best accuracy among prognostic scales for patients with brain metastases (BM). A wide range of...
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Predicting survival after radiosurgery in patients with lung cancer brain metastases using deep learning of radiomics and EGFR status
The early prediction of overall survival (OS) in patients with lung cancer brain metastases (BMs) after Gamma Knife radiosurgery (GKRS) can...
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Predicting survival in melanoma patients treated with concurrent targeted- or immunotherapy and stereotactic radiotherapy
BackgroundMelanoma patients frequently develop brain metastases. The most widely used score to predict survival is the molGPA based on a mixed...
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Analysis of the efficacy of upfront brain radiotherapy versus deferred radiotherapy for EGFR/ALK-positive non-small cell lung cancer with brain metastases: a retrospective study
BackgroundFor brain metastases (BMs) from EGFR/ALK -positive non-small cell lung cancer (NSCLC), the best time to administer tyrosine kinase...
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Therapeutic effect of whole brain radiotherapy on advanced NSCLC between EGFR TKI-naïve and TKI-resistant
BackgroundThe development of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has dramatically improved the prognosis of...
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Stereotactic radiosurgery combined with targeted/ immunotherapy in patients with melanoma brain metastasis
BackgroundThere is limited data on the use of targeted or immunotherapy (TT/IT) in combination with single fraction stereotactic radiosurgery (SRS)...
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Update on the Management of Brain Metastasis
Brain metastases occur in almost one-third of adult patients with solid tumor malignancies and lead to considerable patient morbidity and mortality....
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Hypofractionated frameless gamma knife radiosurgery for large metastatic brain tumors
Hypofractionated stereotactic radiosurgery has become an alternative for metastatic brain tumors (METs). We aimed to analyze the efficacy and safety...
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Relationship between WBRT total dose, intracranial tumor control, and overall survival in NSCLC patients with brain metastases - a single-center retrospective analysis
BackgroundThe relationship between whole brain radiotherapy (WBRT) dose with intracranial tumor control and overall survival (OS) in patients with...
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Validation of the graded prognostic assessment for lung cancer with brain metastases using molecular markers (lung-molGPA)
BackgroundMany patients with brain metastases from non-small cell lung cancer have limited survival, while others survive for several years,...
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Single‐fraction versus hypofractionated gamma knife radiosurgery for small metastatic brain tumors
Stereotactic radiosurgery (SRS) has become a standard of care for the treatment of metastatic brain tumors (METs). Although a better balance of tumor...
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Melanoma with Brain Metastasis
Melanoma is the third most common skin malignancy but is the one with the highest propensity to metastasize, potentially able to disseminate to any...
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Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA)
PurposeThe purpose of this study was to validate a new prognostic model (GI-GPA) originally derived from a multi-center database (USA, Canada, Japan).
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Development of a disease-specific graded prognostic assessment index for the management of sarcoma patients with brain metastases (Sarcoma-GPA)
Abstract BackgroundBrain metastases from sarcomatous lesions pose a management challenge owing to their rarity and the histopathological...
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Combination therapy of brain radiotherapy and EGFR-TKIs is more effective than TKIs alone for EGFR-mutant lung adenocarcinoma patients with asymptomatic brain metastasis
BackgroundThe treatment strategy for brain metastasis (BM) in patients with epidermal growth factor receptor (EGFR) -mutant lung adenocarcinoma (LAC)...
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Management of patients with brain metastases from non-small cell lung cancer and adverse prognostic features: multi-national radiation treatment recommendations are heterogeneous
BackgroundDifferent management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment...
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Are prognostic indices for brain metastases of melanoma still valid in the stereotactic era?
BackgroundMalignant melanoma brain metastases (MBM) are the third most common cause for brain metastases (BM). Historically Whole-brain radiotherapy...
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STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating cells, but successful metastases bypass this...
