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Novel Mutation in the Moesin (MSN) Gene Leads to Immunodeficiency with Epstein–Barr Virus (EBV) Infection and Dermatomyositis-Like Symptoms
PurposeMoesin (MSN) deficiency is a recently reported combined immunodeficiency, and few cases have been reported to date. We describe a Chinese...
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The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration
BackgroundThe cell adhesion molecule transmembrane and immunoglobulin (Ig) domain containing1 (TMIGD1) is a novel tumor suppressor that plays...
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CD44 cross-linking increases malignancy of breast cancer via upregulation of p-Moesin
BackgroundCD44 is highly expressed in most cancer cells and its cross-linking pattern is closely related to tumor migration and invasion. However,...
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Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton
Moesin is a member of the ezrin, radixin and moesin (ERM) proteins that are involved in the formation and/or maintenance of cortical actin...
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Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins
Breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp) are co-located at blood–brain barrier (BBB) cells, preventing their substrates from...
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Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer’s disease
BackgroundProteomic characterization of microglia provides the most proximate assessment of functionally relevant molecular mechanisms of...
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The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome
Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies examining plaque-associated proteins have shown these...
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Podoplanin (PDPN) affects the invasiveness of thyroid carcinoma cells by inducing ezrin, radixin and moesin (E/R/M) phosphorylation in association with matrix metalloproteinases
BackgroundPodoplanin (PDPN) is a mucin-type transmembrane glycoprotein specific to the lymphatic system. PDPN expression has been found in various...
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Rhoj Is a Novel Target for Progression and Invasion of Glioblastoma by Impairing Cytoskeleton Dynamics
Rho GTPase family members were identified as critical regulators of cell morphology, actin cytoskeleton organization, cell movement, and cell cycle...
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Internalization of NKCC2 is impaired in thick ascending limb of Henle in moesin knockout mice
Moesin is expressed in several types of cells including epithelial and endothelial cells. Several groups reported that moesin plays important roles...
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The relationship and clinical significance of lactylation modification in digestive system tumors
Lactylation, an emerging post-translational modification, plays a pivotal role in the initiation and progression of digestive system tumors. This...
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Guillain Barre Syndrome as a Complication of Infections Including COVID-19: a Review
Purpose of ReviewThe purpose was to analyze scientific findings on Guillain Barre Syndrome (GBS) related to COVID-19 and emphasize its relationship...
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ERRα coordinates actin and focal adhesion dynamics
Cell migration depends on the dynamic organisation of the actin cytoskeleton and assembly and disassembly of focal adhesions (FAs). However, the...
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Aging Biomarker SMP30 into a New Phase of Vitamin C and Aging Research
Proteomics has provided comprehensive information in terms of agingAging in general and, in particular, regarding age-associated molecules, including... -
Highlighting the role of CD44 in cervical cancer progression: immunotherapy’s potential in inhibiting metastasis and chemoresistance
Cervical cancer affects thousands of women globally with recurring high-risk HPV infections being at the centre of cervical pathology. Oncological...
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Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer
BackgroundMoesin is a member of the ERM (ezrin, radixin and moesin) proteins that participate in cell migration and tumor invasion through...
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The role of noble bumblebee (Bombus terrestris) queen glycosaminoglycan in aged rat and gene expression profile based on DNA microarray
Glycosaminoglycans (GAGs) have been used to diminish the deleterious effects associated with aging by preventing the destruction of cartilage, bone,...
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PTBP1 plays an important role in the development of gastric cancer
BackgroundPolypyrimidine tract binding protein 1 (PTBP1) has been found to play an important role in the occurrence and development of various...