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Mitochondrial DNA Profiling
Mitochondrial DNA (mtDNA) is a versatile tool in understanding the clinical and non-clinical aspects attributed by the nucleotide sequences. The...
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Molecular basis for maternal inheritance of human mitochondrial DNA
Uniparental inheritance of mitochondrial DNA (mtDNA) is an evolutionary trait found in nearly all eukaryotes. In many species, including humans, the...
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Mitochondrial DNA Mutations in Cardiovascular Diseases
Early prevention of the development and timely diagnosis of cardiovascular system diseases are some of the main problems in modern cardiology. One...
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Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the...
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Mitochondrial DNA mutations in Medulloblastoma
To date, several studies on genomic events underlying medulloblastoma (MB) biology have expanded our understanding of this tumour entity and led to...
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A novel pathogenic mitochondrial DNA variant m.4344T>C in tRNAGln causes developmental delay
Mitochondrial diseases are a group of genetic diseases caused by mutations in mitochondrial DNA and nuclear DNA. However, the genetic spectrum of...
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G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage
Pathogenic mutations in LRRK2 cause Parkinson’s disease (PD). The G2019S variant is the most common, which results in abnormally high kinase...
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The Protective Mechanism of TFAM on Mitochondrial DNA and its Role in Neurodegenerative Diseases
Mitochondrial transcription factor A (TFAM) is a mitochondrial protein encoded by nuclear genes and transported from the cytoplasm to the...
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Simultaneous assessment of mitochondrial DNA copy number and nuclear epigenetic age towards predictive models of development and aging
ObjectiveMitochondrial dysfunction and nuclear epigenetic alterations, two hallmarks of aging, are associated with aberrant development and complex...
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Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
In addition to constituting the genetic material of an organism, DNA is a tracer for the recognition of foreign pathogens and a trigger of the innate...
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Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the...
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Cellular and Molecular Responses to Mitochondrial DNA Deletions in Kearns-Sayre Syndrome: Some Underlying Mechanisms
Kearns-Sayre syndrome (KSS) is a rare multisystem mitochondrial disorder. It is caused by mitochondrial DNA (mtDNA) rearrangements, mostly...
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Mitochondrial DNA Analysis in Population Isolates: Challenges and Implications for Human Identification
Purpose of ReviewMitochondrial DNA (mtDNA) plays an essential role in forensic science, aiding in human identification especially when dealing with...
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Blocking reverse electron transfer-mediated mitochondrial DNA oxidation rescues cells from PANoptosis
PANoptosis is a new type of cell death featured with pyroptosis, apoptosis and necroptosis, and is implicated in organ injury and mortality in...
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DNA Methylation-Mediated Mfn2 Gene Regulation in the Brain: A Role in Brain Trauma-Induced Mitochondrial Dysfunction and Memory Deficits
Repeated mild traumatic brain injuries (rMTBI) affect mitochondrial homeostasis in the brain. However, mechanisms of long-lasting neurobehavioral...
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Plausible Role of Mitochondrial DNA Copy Number in Neurodegeneration—a Need for Therapeutic Approach in Parkinson’s Disease (PD)
Parkinson’s disease (PD) is an advancing age-associated progressive brain disorder which has various diverse factors, among them mitochondrial...
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Arsenic-Induced Cardiovascular Diseases and their Correlation with Mitochondrial DNA Copy Number, Deletion, and Telomere Length in Bangladeshi Population
Arsenic contamination is a global health concern, primarily through contaminated groundwater and its entry into the food chain. The association...
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Measurement of Cytosolic Mitochondrial DNA After NLRP3 Inflammasome Activation
The NLRP3 inflammasome, a key component of the innate immune system that mediates caspase-1 activation, which in turn induces cleavage of the...
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Validating a Mitochondrial Sweep Accompanying the Rapid Spread of a Maternally Inherited Symbiont
Maternally inherited symbiotic bacteria that interfere with the reproduction of their hosts can contribute to selective sweeps of mitochondrial...