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Optogenetics and Light-Sheet Microscopy
Light-sheet microscopy is a powerful method for imaging small translucent samples in vivo, owing to its unique combination of fast imaging speeds,...
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Microscopy
The microbial world comprises diverse organisms with a wide range of cellular and molecular organisations. The disease-causing agents may be...
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Epifluorescence Microscopy
In previous chapters, we have seen that the interaction of light with matter produces one or a combination of the following phenomena: transmission,...
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Surface Glutamate Receptor Nanoscale Organization with Super-Resolution Microscopy (dSTORM)
Glutamate receptors mediate the majority of excitatory transmission in the central nervous system. Recent developments in super-resolution...
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Observation of Bacteriophage Ultrastructure by Cryo-Electron Microscopy
Transmission electron microscopy (TEM) is an ideal method to observe and determine the structure of bacteriophages. From early studies by negative...
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Electron Microscopy
The observations made by Robert Hooke (1635–1703) and Antonie van Leeuwenhoek (1632–1723) with the first optical microscope awakened man’s will to...
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Confocal and Multiphoton Microscopy
Confocal and multiphoton microscopy are considered advanced instruments in the field of light microscopy due to the complexity of the optical and...
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Spinning Disk Microscopy
Spinning disk microscopy is a specialized imaging technique utilized with living and light sensitive samples. Arrays of optical pinholes spun at high...
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High-Speed Neural Imaging with Synaptic Resolution: Bessel Focus Scanning Two-Photon Microscopy and Optical-Sectioning Widefield Microscopy
Brain is composed of complex networks of neurons that work in concert to underlie the animal’s cognition and behavior. Neurons communicate via...
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Stimulated Emission Depletion Microscopy
Stimulated emission depletion (STED) microscopy is in its simplest form an extension of confocal fluorescence microscopy that offers much enhanced...
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Evaluation of Mesenteric Microvascular Hyperpermeability Following Hemorrhagic Shock Using Intravital Microscopy
Intravital microscopy is a powerful tool for evaluating vascular hyperpermeability in various vascular beds. Hemorrhagic shock after traumatic injury...
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Multiplexing and Spectral Microscopy
Visualization of proteins within a tissue sample via immunohistochemistry (IHC) is a central aspect of pathology. However, such methods are limited...
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Advances in Microscopy
Microscope is the only instrument that enables us to visualize any organism or cellular structure because we cannot see such structures with our...
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Advanced Topics in Quantitative Acoustic Microscopy
Quantitative acoustic microscopy (QAM) reconstructs two-dimensional (2D) maps of the acoustic properties of thin tissue sections. Using ultrahigh...
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Determination of Blood-Brain Barrier Hyperpermeability Using Intravital Microscopy
The blood vessels that vascularize the central nervous system (CNS) exhibit unique properties, termed the blood-brain barrier (BBB). The BBB allows...
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COVID-19 Adaptations with Virtual Microscopy
This chapter aims to discuss and compare the different approaches used to teach histology to dental students before and during the COVID-19 pandemic...
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Mouse Brain Tissue Preparation for Scanning Electron Microscopy
Scanning electron microscopy (SEM) is used to observe the surface structure of an object by irradiating an electron beam onto the sample and...
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Advances in microscopy characterization techniques for lipid nanocarriers in drug delivery: a comprehensive review
This review paper provides an in-depth analysis of the significance of lipid nanocarriers in drug delivery and the crucial role of characterization...
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Expansion Microscopy of Mouse Photoreceptor Cilia
The small size of ciliary structures that underlies photoreceptor function and inherited ciliopathies requires imaging techniques adapted to...
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Visualizing Neurodegeneration Using Atomic Force Microscopy
Neurodegeneration can be described as a progressive damage and eventually death of neuronal cells, affecting the proper function of the whole of the...