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MiRNA Immunity Against Virus and MiRNA Surveillance Against Tumor
Through the microRNA (miRNA) entangling target sorting/quantum miRNA language plus artificial intelligence (METS/MIRAI) analysis so far, it seems...
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miRNA Dysregulation in Schizophrenia
Schizophrenia is a complex neuropsychiatric disorder that alters synapse activity as well as neural circuits. An intricate intracellular network of...
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Oxford miRNA Gardener
Genetic traits are a curious question for biological research to elucidate the etiology of pathogenesis and are transmitted from cell to cell,...
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Quantum MiRNA Code
The C. elegans’s lin-4 discovery in 1993 to date are still limited to C. elegans-specific RNA interference. The function of microRNA (miRNA) is based...
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Experimental capture of miRNA targetomes: disease-specific 3′UTR library-based miRNA targetomics for Parkinson’s disease
The identification of targetomes remains a challenge given the pleiotropic effect of miRNAs, the limited effects of miRNAs on individual targets, and...
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Programmed Evolution by miRNA Memory
Diseases are deeply implicated in the aberrant expression of microRNA (miRNA) genes. The RNA Wave 2000 dogma consists of four criteria, as first...
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Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets
Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is regulated by over 40 enzymes, targeting more than...
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miRNA profiling of primary lamb testicle cells infected with lumpy skin disease virus
In this study, miRNA profiling of cells infected with lumpy skin disease virus (LSDV) was conducted for the first time. When compared to...
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Exosomal miRNA-146a and miRNA-424 as Possible Predictors of Immune Checkpoint Inhibitors Therapy Response in Clear Cell Renal Cell Carcinoma
AbstractClear cell renal cell carcinoma (ccRCC) is a malignant kidney tumour with a poor prognosis and difficult to treat. Despite significant...
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Identification and bioinformatic characterization of a serum miRNA signature for early detection of laryngeal squamous cell carcinoma
BackgroundThe growing understanding of cancer biology and the establishment of new treatment modalities has not yielded the expected results in terms...
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Crosstalk Between miRNA and Protein Expression Profiles in Nitrate-Exposed Brain Cells
Growing evidence reported a strong association between the nitrate ingestion and adverse health consequences in humans, including its detrimental...
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Identification of miRNA expression profile in middle ear cholesteatoma using small RNA-sequencing
BackgroundThe present study aims to identify the differential miRNA expression profile in middle ear cholesteatoma and explore their potential roles...
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Exosomal miRNA-328-3p targets ZO-3 and inhibits porcine epidemic diarrhea virus proliferation
As essential transfer carriers for cell-to-cell communication and genetic material, exosomes carry microRNAs that participate in the regulation of...
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RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21
BackgroundPrior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6) translocates to the nucleolus in response to cytotoxic stress...
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Targeting miRNA and using miRNA as potential therapeutic options to bypass resistance in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor prognosis due to early metastasis, low diagnostic rates at early...
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Phytochemicals and miRNA-Based Therapeutic Opportunities for Cancer Stem Cell-Mediated Tumor Angiogenesis
Cancer stem cell (CSC) is a small subset of cancer cell population with unique ability to self-renew. They are responsible for invasion and...
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Functionalized siRNA-chitosan nanoformulations promote triple-negative breast cancer cell death via blocking the miRNA-21/AKT/ERK signaling axis: in-silico and in vitro studies
Oncogenic microRNA (miRNA), especially miRNA-21 upregulation in triple-negative breast cancer (TNBC), suggests a new class of therapeutic targets. In...
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RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within
Recent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of...
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Transcriptome Profiling of miRNA-mRNA Interactions and Associated Mechanisms in Chemotherapy-Induced Neuropathic Pain
Chemotherapy-induced neuropathic pain (CINP) is a dose-limiting adverse event affecting 40% of chemotherapy patients. MiRNA-mRNA interaction plays an...
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FAS-mediated circRNA-miRNA-mRNA Crosstalk Network Regulates Immune Cell Infiltration in Cerebral Infarction
New data are accumulating on the involvement of interaction among circular RNAs (circRNAs), microRNAs (miRNAs/miRs), and messenger RNAs (mRNAs) in...
