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LncRNA HCG11 promotes proliferation and migration in gastric cancer via targeting miR-1276/CTNNB1 and activating Wnt signaling pathway
BackgroundGastric cancer (GC) is one common cancer which occurs in the stomach leading to high mortality around the world. Long non-coding RNAs...
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Hsa_circ_0000069 Accelerates Cervical Cancer Progression by Sponging miR-1270 to Facilitate CPEB4 Expression
The critical importance of circular RNAs (circRNAs) in human cancers, including cervical cancer (CC), has been discovered in recent years. However,...
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FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway
BackgroundLong non-coding RNAs (lncRNAs) are extensively intricate in the tumorigenesis and metastasis of various cancer types. Nevertheless, the...
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The functional roles of the circRNA/Wnt axis in cancer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were...
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MicroRNAs as Tools for Early Diagnosis and Predicting Responses to Therapy in Oesophageal Cancer
Oesophageal cancer (EC) is an aggressive and invasive cancer with limited diagnosis and survival. EC usually occurs as either oesophageal...
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LINC00536 Promotes Breast Cancer Progression by Regulating ROCK1 via Sponging of miR-214-5p
Accumulating evidence has shown that long noncoding RNAs (lncRNAs) play a significant role in regulating gene expression and participating in the...
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HIF-2α/LINC02609/APOL1-mediated lipid storage promotes endoplasmic reticulum homeostasis and regulates tumor progression in clear-cell renal cell carcinoma
BackgroundThe VHL-HIF pathway and lipid droplet accumulation are the main characteristics of clear cell renal cell carcinoma (ccRCC). However, the...
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Hypoxia-induced circRNF13 promotes the progression and glycolysis of pancreatic cancer
Pancreatic cancer (PC) is one of the most malignant tumors. Rapid progression and distant metastasis are the main causes of patient death. Hypoxia is...
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The Expression Analysis of Long Non-coding RNAs Related to Wnt/β-Catenin Signaling in Pancreatic Cancer Patients
Background The oncogenic Wnt/ β -catenin signaling plays a critical role in carcinogenesis, prognosis, and resistance to therapy. Pancreatic cancer...
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Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer
BackgroundThe underlying circular RNAs (circRNAs)-related competitive endogenous RNA (ceRNA) mechanisms of pathogenesis and prognosis in non-small...
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Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19
COVID-19 continues to affect an unprecedented number of people with the emergence of new variants posing a serious challenge to global health. There...
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Identification and development of a novel 5-gene diagnostic model based on immune infiltration analysis of osteoarthritis
BackgroundOsteoarthritis (OA), which is due to the progressive loss and degeneration of articular cartilage, is the leading cause of disability...
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Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated macrophage activation by ERK pathway to accelerate liver injury
AbstractLiver injury is closely associated with macrophage activation following HBV infection. Our previous study showed that only HBeAg, but not...
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Racial differences in RAD51 expression are regulated by miRNA-214-5P and its inhibition synergizes with olaparib in triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) affects young women and is the most aggressive subtype of breast cancer (BC). TNBCs disproportionally...
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A circRNA–miRNA–mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma
BackgroundCircular RNAs (circRNAs) have received increasing attention in human tumor research. However, there are still a large number of unknown...
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Challenges of mesenchymal stem cells in the clinical treatment of COVID-19
The 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought an enormous public health...
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Development and validation of novel inflammatory response-related gene signature for sepsis prognosis
Due to the low specificity and sensitivity of biomarkers in sepsis diagnostics, the prognosis of sepsis patient outcomes still relies on the...
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Cytokine-enhanced cytolytic activity of exosomes from NK Cells
Natural killer (NK) cells play key roles in immune surveillance against tumors and viral infection. NK cells distinguish abnormal cells from healthy...
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Infection, dissemination, and transmission efficiencies of Zika virus in Aedes aegypti after serial passage in mosquito or mammalian cell lines or alternating passage in both cell types
BackgroundZika virus (ZIKV) is an arthropod-borne virus (arbovirus) with an urban transmission cycle that primarily involves humans and Aedes aegypti. ...
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RETRACTED ARTICLE: Circular RNA circ-CSPP1 regulates CCNE2 to facilitate hepatocellular carcinoma cell growth via sponging miR-577
ObjectiveCirc-centro-some/spindle pole-associated protein (CSPP1) has been confirmed to be characterized in diverse human malignancies and its...
