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Integrative analysis of transcriptomic and metabolomic profiles reveals enhanced arginine metabolism in androgen-independent prostate cancer cells
BackgroundProstate cancer is a common solid tumor that affects a significant number of men worldwide. Conventional androgen deprivation therapy (ADT)...
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Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment
We performed liquid chromatography tandem mass spectrometry analysis with the targeted metabolomic kit Biocrates MxP Quant 500, in human brain cortex...
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Phenotypic and metabolomic characteristics of mouse models of metabolic associated steatohepatitis
BackgroundMetabolic associated steatohepatitis (MASH) is metabolic disease that may progress to cirrhosis and hepatocellular carcinoma. Mouse models...
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High-Throughput Combined Analysis of Saliva Microbiota and Metabolomic Profile in Chinese Periodontitis Patients: A Pilot Study
The onset and progression of periodontitis involves complicated interactions between the dysbiotic oral microbiota and disrupted host...
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Targeted Metabolomic Biomarkers for Stroke Subty**
Background and PurposeIschemic stroke is a heterogeneous disease with various etiologies. The current subty** process is complicated,...
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Metabolomic profiles predict individual multidisease outcomes
Risk stratification is critical for the early identification of high-risk individuals and disease prevention. Here we explored the potential of...
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Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes
BackgroundProstate cancer (PC) is a heterogenous multifocal disease ranging from indolent to lethal states. For improved treatment-stratification,...
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Microbiome and Metabolomic Biomarkers for Huntington’s Disease
Huntington’s disease (HD) is a fatal monogenic neurodegenerative disorder caused by the expansion of the trinucleotide tandem repeat in the...
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Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
BackgroundB vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methylation. Several...
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A metabolomic analysis of adiposity measures and pre- and postmenopausal breast cancer risk in the Nurses’ Health Studies
BackgroundAdiposity is consistently positively associated with postmenopausal breast cancer and inversely associated with premenopausal breast cancer...
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Integrated pathway and network analyses of metabolomic alterations in peripheral blood of patients with depression
Depression is a serious mental illness, but the molecular mechanisms of depression remain unclear. Previous research has reported metabolomic changes...
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Metabolomic Biomarkers in Parkinson’s Disease
Metabolomics analysis has developed rapidly in recent decades and has become a powerful tool to understand comprehensive metabolic changes in...
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Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians
BackgroundType 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the...
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Metabolomic phenoty** of obesity for profiling cardiovascular and ocular diseases
BackgroundWe aimed to evaluate the impacts of metabolomic body mass index (metBMI) phenotypes on the risks of cardiovascular and ocular diseases...
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Tracer-Based Cancer Metabolomic Analysis
Metabolic rewiring/reprogramming is an essential hallmark of cancer. Alteration of metabolic phenotypes is occurred in cancer cells in response to a...
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Acute venous thromboembolism plasma and red blood cell metabolomic profiling reveals potential new early diagnostic biomarkers: observational clinical study
BackgroundVenous thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is based on complex imaging exams...
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Metabolomic discoveries for early diagnosis and traditional Chinese medicine efficacy in ischemic stroke
Ischemic stroke (IS), a devastating cerebrovascular accident, presents with high mortality and morbidity. Following IS onset, a cascade of...
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Recent metabolomic developments for antimalarial drug discovery
Malaria is a parasitic disease that remains a global health issue, responsible for a significant death and morbidity toll. Various factors have...
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Ion Chromatography with Mass Spectrometry for Metabolomic Analysis
Ion chromatography (IC) represents an important technique for separation of charged and polar compounds. Traditionally, IC is often used for the...
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Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies
BackgroundAcute gouty arthritis is inflammatory joint arthritis. Gouty arthritis (GA) involves multiple pathological processes. Deposition of joints...
