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Methods to Measure Water Permeability
Water permeability is a key feature of the cell plasma membranes, and it has seminal importance for several cell functions such as cell volume...
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Tricaprin as a membrane permeability regulator: sustained small hydrophilic substance release from liposomes
PurposeIncorporating fatty acids into the phospholipid bilayer affects membrane packing order and permeability. We recently demonstrated that...
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Establishment of the deuterium oxide dilution method as a new possibility for determining the transendothelial water permeability
Increase in transendothelial water permeability is an essential etiological factor in a variety of diseases like edema and shock. Despite the high...
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Non-Aquaporin Water Channels
Water transport through membrane is so intricate that there are still some debates. AQPs are entirely accepted to allow water transmembrane movement...
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Determination of Solute Permeability of Microvascular Endothelial Cell Monolayers In Vitro
The microvascular endothelium has a critical role in regulating the delivery of oxygen, nutrients, and water to the surrounding tissues. Under...
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Updated Evaluation of Cholesterol’s Influence on Membrane Oxygen Permeability
There is a surprising gap in knowledge regarding the mechanism of oxygen (O2) diffusional delivery at the level of tissues and cells. Yet, the...
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Filter exchange imaging with crusher gradient modelling detects increased blood–brain barrier water permeability in response to mild lung infection
Blood–brain barrier (BBB) dysfunction occurs in many brain diseases, and there is increasing evidence to suggest that it is an early process in...
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Influence of Bile Acids on Clindamycin Hydrochloride Skin Permeability: In Vitro and In Silico Preliminary Study
Background and ObjectiveTopical clindamycin formulations are widely used in clinical practice, but poor bioavailability and restricted skin...
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Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides
PurposeTo develop a novel, target agnostic liposome click membrane permeability assay (LCMPA) using liposome encapsulating copper free click reagent...
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Estimating the Ca2+ Permeability of NMDA Receptors with Whole-Cell Patch-Clamp Electrophysiology
In the mammalian central nervous system (CNS), fast excitatory transmission relies primarily on the ionic fluxes generated by ionotropic glutamate...
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METTL3 Mediates Microglial Activation and Blood–Brain Barrier Permeability in Cerebral Ischemic Stroke by Regulating NLRP3 Inflammasomes Through m6A Methylation Modification
Cerebral ischemic stroke (CIS) is the main cause of disability. METTL3 is implicated in CIS, and we explored its specific mechanism. Middle cerebral...
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Characterization of critical parameters using an air–liquid interface model with RPMI 2650 cells for permeability studies of small molecules
The field of nasal drug delivery gained enormously on interest over the past decade. Performing nasal in vivo studies is expensive and...
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An In Vitro Bilayer Model of Human Primary Retinal Pigment Epithelial and Choroid Endothelial Cells for Permeability Studies
The blood-retinal barrier (BRB) present in the posterior chamber of the eye plays a major role in maintaining the proper function and integrity of...
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Computational Analysis of the Effects of Fiber Deformation on the Microstructure and Permeability of Blood Oxygenator Bundles
Mechanical loads on the polymeric fibers of oxygenating bundles are commonly present due to bundle press-fitting during device assembly and blood...
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TFAM-Mediated mitochondrial transfer of MSCs improved the permeability barrier in sepsis-associated acute lung injury
Vascular endothelial cell barrier disruption is a hallmark of sepsis-induced acute lung injury (ALI). Mesenchymal stem cells (MSCs)-based therapy has...
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Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath
BackgroundAstrocyte endfoot processes are believed to cover all micro-vessels in the brain cortex and may play a significant role in fluid and...
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Functionalized Fluoropolymer Membrane for Fuel Cell Applications
Polymeric membrane has been the key component of research in view of the fact that previous few decades had newest enhancement in both production and...
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Mertk Reduces Blood-Spinal Cord Barrier Permeability Through the Rhoa/Rock1/P-MLC Pathway After Spinal Cord Injury
Disruption of the blood-spinal cord barrier (BSCB) is a critical event in the secondary injury following spinal cord injury (SCI). Mertk has been...
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Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome
BackgroundPreclinical studies in acute respiratory distress syndrome (ARDS) have suggested that inhaled sevoflurane may have lung-protective effects...
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Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals
PurposeThere is growing interest in seeking pharmacological activation of neurolysin (Nln) for stroke treatment. Discovery of central nervous system...
