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Mitochondrial Regulation of Macrophages in Innate Immunity and Diverse Roles of Macrophages During Cochlear Inflammation
Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and...
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Integrated analysis of tumor-associated macrophages and M2 macrophages in CRC: unraveling molecular heterogeneity and develo** a novel risk signature
BackgroundEmerging investigations have increasingly highlighted the critical role of tumor-associated macrophages (TAMs) and M2 macrophages in cancer...
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IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
BackgroundMultiple sclerosis (MS) is a neuroinflammatory demyelinating disease characterized by motor deficits and cognitive decline. Many immune...
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Targeting Macrophages for Tumor Therapy
Macrophages, as one of the most abundant tumor-infiltrating cells, play an important role in tumor development and metastasis. The frequency and...
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Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages
BackgroundMacrophages play a crucial role in the development of cardiac fibrosis (CF). Although our previous studies have shown that glycogen...
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Function of alveolar macrophages in lung cancer microenvironment
BackgroundCancer tissues contain a wide variety of immune cells that play critical roles in suppressing or promoting tumor progression. Macrophages...
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Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Remote organ injury, which is a common secondary complication of sterile tissue damage, is a major cause of poor prognosis and is difficult to...
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Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages
BackgroundMyelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple...
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Imaging of Tumor-Associated Macrophages
Tumor-associated macrophages (TAMs) are among the first non-tumoral cells that infiltrate the tumor microenvironment (TME) and encompass up to half...
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Targeted liposomes for macrophages-mediated pulmonary fibrosis therapy
Pulmonary fibrosis (PF) is a horrible lung disease that causes pulmonary ventilation dysfunction and respiratory failure, severely impacting...
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Using siRNA Silencing to Analyze ADAM17 in Macrophages
Silencing expression with short interfering RNA (siRNA) is a rapid and cost-effective way to analyze the involvement of target genes in a range of...
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Roles of macrophages in tumor development: a spatiotemporal perspective
Macrophages are critical regulators of tissue homeostasis but are also abundant in the tumor microenvironment (TME). In both primary tumors and...
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Live Imaging of Pyroptosis in Primary Murine Macrophages
Inflammasomes are the ultimate weapon of the macrophage immune arsenal. Inflammasome signalling in macrophages triggers pyroptosis, a lytic cell...
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Understanding the Role of Scavenger Receptor A1 in Nanoparticle Uptake by Murine Macrophages
Nanoparticles can be cleared from the circulation and taken up by tissue-resident macrophages. This property can be beneficial when drug or antigen...
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Border-associated macrophages in the central nervous system
Tissue-resident macrophages play an important role in the local maintenance of homeostasis and immune surveillance. In the central nervous system...
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Regional differences in the ultrastructure of mucosal macrophages in the rat large intestine
We previously clarified the histological characteristics of macrophages in the rat small intestine using serial block-face scanning electron...
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Tissue-resident C1q + macrophages exert anti-aging potential through the Sirt1 pathway
ObjectiveResident immune cells are at the forefront of sensory organ-specific signals, and changes in these cells are closely related to the aging...
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Depleting profibrotic macrophages using bioactivated in vivo assembly peptides ameliorates kidney fibrosis
Managing renal fibrosis is challenging owing to the complex cell signaling redundancy in diseased kidneys. Renal fibrosis involves an immune response...
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Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming
Macrophages are highly plastic in different tissues and can differentiate into functional subpopulations under different stimuli. Tumor-associated...
