Search
Search Results
-
Oligonucleotides and mRNA Therapeutics
Two important classes of therapeutics based on nucleic acids are synthetic oligonucleotides and mRNA generated by in vitro transcription (IVT)....
-
DYNLL1 transcript abundance decreases during oocyte and follicular growth and is associated with fertility in mice
DNA repair efficiency is an important determinant of oocyte quality and female fertility. DYNLL1 (Dynein light chain 1) plays a part in DNA...
-
Selection on synonymous sites: the unwanted transcript hypothesis
Although translational selection to favour codons that match the most abundant tRNAs is not readily observed in humans, there is nonetheless...
-
Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA
To elicit optimal immune responses, messenger RNA vaccines require intracellular delivery of the mRNA and the careful use of adjuvants. Here we...
-
Nuclear mRNA Export Measurement Using FISH in iPSC-Derived Neurons
Nucleocytoplasmic transport (NCT) across the nuclear envelope plays a critical role in maintaining cellular homeostasis. Impaired NCT has been shown...
-
2020: The Triumph of Anti-Covid mRNA Vaccines
Starting in the fall of 2019, the story of mRNA vaccines becomes closely tied to the emergence of the coronavirus pandemic. This is the “tip of the...
-
The + 3010/C single nucleotide polymorphism (rs1710) at the HLA-G 3′ untranslated region is associated with a short transcript exhibiting a deletion of 92 nucleotides
The physiological expression of HLA-G is mainly observed in the placenta, playing an essential role in maternal–fetal tolerance. Among the HLA-G mRNA...
-
Tailor made: the art of therapeutic mRNA design
mRNA medicine is a new and rapidly develo** field in which the delivery of genetic information in the form of mRNA is used to direct therapeutic...
-
CREB-Binding Protein Regulates Cocaine- and Amphetamine-Regulated Transcript Peptide Expression in the Lateral Hypothalamus: Implication in Reward and Reinforcement
Neuropeptide cocaine- and amphetamine-regulated transcript peptide (CARTp) is known to play an important role in reward processing. The rats...
-
The mRNA and the New Vaccines
The messenger RNA molecules provide the order in which the amino acids are linked together, via a register of three-nucleotide sequences (codons)....
-
HSV-1 latency-associated transcript miR-H3 and miR-H4 target STXBP1 and GABBR2 genes
During latent infection, the HSV-1 virus generates only a single transcript, LAT, which encodes six miRNAs. The GABAergic pathway signaling system is...
-
SMAD4–201 transcript as a putative biomarker in colorectal cancer
BackgroundTranscripts with alternative 5′-untranslated regions (UTRs) result from the activity of alternative promoters and they can determine gene...
-
Nuclear mRNA decay: regulatory networks that control gene expression
Proper regulation of mRNA production in the nucleus is critical for the maintenance of cellular homoeostasis during adaptation to internal and...
-
Zebrafish cardiac repolarization does not functionally depend on the expression of the hERG1b-like transcript
Zebrafish provide a translational model of human cardiac function. Their similar cardiac electrophysiology enables screening of human cardiac...
-
Appraisal of Some of the Key Postulates Underlying mRNA Vaccines
As described in the introduction, key foundational assumptions (Fig. 1.1 ) have guided the approval and...
-
Risk SNP in a transcript of RP11-638I2.4 increases lncRNA–YY1 interaction and pancreatic cancer susceptibility
Tens of thousands of long non-coding RNAs (lncRNAs) have been identified through RNA-seq analysis, but the biological and pathological significance...
-
The linear ANRIL transcript P14AS regulates the NF-κB signaling to promote colon cancer progression
BackgroundThe linear long non-coding RNA P14AS has previously been reported to be dysregulated in colon cancer, but the mechanistic role that P14AS ...
-
The Protective Role of Transcript-Induced in Spermiogenesis 40 in Cerebral Ischemia–Reperfusion Injury
Prompt reperfusion after cerebral ischemia is important to maintain neuronal survival and reduce permanent disability and death. However, the...
-
The Novel Frameshift Variant of the MYBPC3 Gene Associated with Hypertrophic Cardiomyopathy Significantly Decreases the Level of This Gene Transcript in the Myocardium
Abstract —Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease with a prevalence of 1 : 200–1 : 500 in the general population....
-
The role of alternative pre-mRNA splicing in cancer progression
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the...
