Search
Search Results
-
Landscape genomics reveals adaptive genetic differentiation driven by multiple environmental variables in naked barley on the Qinghai-Tibetan Plateau
Understanding the local adaptation of crops has long been a concern of evolutionary biologists and molecular ecologists. Identifying the adaptive...
-
Advancing genomics to improve health equity
Health equity is the state in which everyone has fair and just opportunities to attain their highest level of health. The field of human genomics has...
-
Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma
BackgroundSystemic therapy for metastatic clear cell sarcoma (CCS) bearing EWSR1-CREB1/ATF1 fusions remains an unmet clinical need in children,...
-
Role of Genomics and Proteomics in Drug Discovery
Genomics and proteomics are two powerful technologies that are revolutionizing the drug discovery process. Genomics is the study of the entire genome...
-
Establishing African genomics and bioinformatics programs through annual regional workshops
The African BioGenome Project (AfricaBP) Open Institute for Genomics and Bioinformatics aims to overcome barriers to capacity building through its...
-
Heterogeneity and molecular landscape of melanoma: implications for targeted therapy
Uveal cancer (UM) offers a complex molecular landscape characterized by substantial heterogeneity, both on the genetic and epigenetic levels. This...
-
Transitioning single-cell genomics into the clinic
The use of genomics is firmly established in clinical practice, resulting in innovations across a wide range of disciplines such as genetic...
-
A systematic analysis of deep learning in genomics and histopathology for precision oncology
BackgroundDigitized histopathological tissue slides and genomics profiling data are available for many patients with solid tumors. In the last 5...
-
Determining the utility of diagnostic genomics: a conceptual framework
BackgroundDiagnostic efficacy is now well established for diagnostic genomic testing in rare disease. Assessment of overall utility is emerging as a...
-
A dynamic systems view of clinical genomics: a rich picture of the landscape in Australia using a complexity science lens
BackgroundClinical genomics represents a paradigm shifting change to health service delivery and practice across many conditions and life-stages....
-
Deep learning in cancer genomics and histopathology
Histopathology and genomic profiling are cornerstones of precision oncology and are routinely obtained for patients with cancer. Traditionally,...
-
Deciphering cancer cell state plasticity with single-cell genomics and artificial intelligence
Cancer stem cell plasticity refers to the ability of tumour cells to dynamically switch between states—for example, from cancer stem cells to...
-
Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases
Human pluripotent stem (hPS) cells can, in theory, be differentiated into any cell type, making them a powerful in vitro model for human biology....
-
Genomics and Functional Genomics of Alzheimer’s Disease
Alzheimer’s disease (AD) is a complex and multifactorial neurodegenerative disease. Due to its long clinical course and lack of an effective...
-
Recent advances in CRISPR-based functional genomics for the study of disease-associated genetic variants
Advances in sequencing technology have greatly increased our ability to gather genomic data, yet understanding the impact of genetic mutations,...
-
Genomic Landscape of Meningiomas
Despite being the most common primary brain tumor in adults, until recently, the genomics of meningiomas have remained quite understudied. In this...
-
Current advances in primate genomics: novel approaches for understanding evolution and disease
Primate genomics holds the key to understanding fundamental aspects of human evolution and disease. However, genetic diversity and functional...
-
Queensland Genomics: an adaptive approach for integrating genomics into a public healthcare system
The establishment of genomics in health care systems has been occurring for the past decade. It is recognised that implementing genomics within a...
-
-
Anoikis-related signature predicts prognosis and characterizes immune landscape of ovarian cancer
Ovarian cancer (OV) is the most lethal gynecological malignancy worldwide, with high recurrence rates. Anoikis, a newly-acknowledged form of...
