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Molecular surveillance of Kelch-13 gene in Plasmodium falciparum field isolates from Mayurbhanj District, Odisha, India, and in silico artemisinin-Kelch-13 protein interaction study
The global malaria control and elimination program faces major threats due to the emergence and transmission of the anti-malarial drug-resistant...
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Kelch-like proteins in the gastrointestinal tumors
Gastrointestinal tumors have become a worldwide health problem with high morbidity and poor clinical outcomes. Chemotherapy and surgery, the main...
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Molecular surveillance of Kelch 13 polymorphisms in Plasmodium falciparum isolates from Kenya and Ethiopia
BackgroundTimely molecular surveillance of Plasmodium falciparum kelch 13 ( k13 ) gene mutations is essential for monitoring the emergence and...
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Exploring the inhibitory potentials of Momordica charantia bioactive compounds against Keap1-Kelch protein using computational approaches
The search for Keap1 inhibitors as potential Nrf2 activator is a way of increasing the antioxidant status of the human cellular environ. In this...
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Molecular surveillance of drug resistance: Plasmodium falciparum artemisinin resistance single nucleotide polymorphisms in Kelch protein propeller (K13) domain from Southern Pakistan
BackgroundK13 propeller ( k13 ) polymorphism are useful molecular markers for tracking the emergence and spread of artemisinin resistance in Plasmodium...
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Kelch 13-propeller polymorphisms in Plasmodium falciparum from Jazan region, southwest Saudi Arabia
BackgroundArtemisinin-based combination therapy (ACT) is recommended at the initial phase for treatment of Plasmodium falciparum , to reduce...
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Anti-malarial resistance in Mozambique: Absence of Plasmodium falciparum Kelch 13 (K13) propeller domain polymorphisms associated with resistance to artemisinins
BackgroundMalaria remains one of the most serious public health problems in sub-Saharan Africa and Mozambique is the world's fourth largest...
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X-linked intellectual disability related to a novel variant of KLHL15
Kelch-like (KLHL) 15, localized on chromosome Xp22.11, was recently identified as an X-linked intellectual disability gene. Herein, we report a case...
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TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling
BackgroundDrug resistance limits the treatment effect of cisplatin-based chemotherapy in head and neck squamous cell carcinoma (HNSCC), and the...
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Targeted deep amplicon sequencing of kelch 13 and cytochrome b in Plasmodium falciparum isolates from an endemic African country using the Malaria Resistance Surveillance (MaRS) protocol
BackgroundRoutine molecular surveillance for imported drug-resistant malaria parasites to the USA and European Union is an important public health...
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The plant-like protein phosphatase PPKL regulates parasite replication and morphology in Toxoplasma gondii
BackgroundThe protozoan parasite Toxoplasma gondii encodes dozens of phosphatases, among which a plant-like phosphatase absent from mammalian...
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The prevalence of Pfk13 polymorphism in malaria patients treated with artemisinin-based therapy: a systematic review and meta-analysis
Artemisinin (ART) combination therapy is the main treatment for malaria. Pfk13 mutations (or K13 mutations, Kelch 13) are associated with ART...
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Engineered Bacillus subtilis alleviates intestinal oxidative injury through Nrf2-Keap1 pathway in enterotoxigenic Escherichia coli (ETEC) K88-infected piglet
Engineered probiotics can serve as therapeutics based on their ability of produce recombinant immune-stimulating properties. In this study, we built...
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Neuroprotective effects of rutin against cuprizone-induced multiple sclerosis in mice
Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system that injures the myelin sheath, provoking...
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In vitro delayed response to dihydroartemisinin of malaria parasites infecting sickle cell erythocytes
BackgroundDecreased efficacy of artemisinin-based combination therapy (ACT) for Plasmodium falciparum malaria has been previously reported in...
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Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar
BackgroundArtemisinin resistance in Plasmodium falciparum threatens global malaria elimination efforts. To contain and then eliminate artemisinin...
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A review of how the saffron (Crocus sativus) petal and its main constituents interact with the Nrf2 and NF-κB signaling pathways
The primary by-product of saffron ( Crocus sativus ) processing is saffron petals, which are produced in large quantities but are discarded. The...
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Lycium barbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress, protecting mitochondrial function, and regulating metabolic pathways
The development of acute liver injury can result in liver cirrhosis, liver failure, and even liver cancer, yet there is currently no effective...
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Antioxidant System and Endoplasmic Reticulum Stress in Cataracts
The primary underlying contributor for cataract, a leading cause of vision impairment and blindness worldwide, is oxidative stress. Oxidative stress...
