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Leishmanicidal and immunomodulatory activities of the formononetin (a natural isoflavone) against Leishmania tropica
ObjectiveThis work aimed to examine the leishmanicidal, cellular mechanisms and cytotoxicity effects of formononetin (FMN), a natural isoflavone,...
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Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells
The functional role of autophagy in regulating differentiation of bone marrow mesenchymal stem cells (MSCs) has been studied extensively, but the...
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Activity of isoflavone biochanin A in chronic experimental toxoplasmosis: impact on inflammation
Toxoplasma gondii is a worldwide prevalent parasite. The infection has been linked to variable inflammatory effects including neuroinflammation....
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The isoflavone genistein enhances osteoblastogenesis: signaling pathways involved
Phytoestrogens have been proposed as a natural therapy for prevention of bone loss. In this work, we studied the mechanism of action of genistein on...
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Methylation of Exogenous Promoters Regulates Soybean Isoflavone Synthase (GmIFS) Transgene in T0 Transgenic Wheat (Triticum aestivum)
AbstractDNA methylation is one epigenetic strategy for gene regulation in living organisms. In this study, the expression of soybean isoflavone...
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New isoflavone glucosides in yabumame (Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var. japonica (Oliv.) H.Ohashi) and their effect on leukotriene B4 production in mast cells
AbstractYabumame ( Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var. japonica (Oliv.) H.Ohashi) is a legume plant that...
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Glycitein prevents reserpine-induced depression and associated comorbidities in mice: modulation of lipid peroxidation and TNF-α levels
Depression is a debilitating mood disorder affecting millions worldwide and continues to pose a significant global health burden. Due to the...
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Proteomics study on the protective mechanism of soybean isoflavone against inflammation injury of bovine mammary epithelial cells induced by Streptococcus agalactiae
This study aimed to verify the anti-inflammatory effect of soybean isoflavones (SI) on the inflammatory response induced by Streptococcus agalactiae (
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Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship
Secondary plant metabolites from food extracts, namely daidzein, quercetin, and luteolin, exhibit anti-influenza virus effects, with IC 50 values of...
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Genistein: a promising modulator of apoptosis and survival signaling in cancer
Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In...
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Synthesis of alkoxy-isoflavones as potential α-glucosidase inhibitors
The aim of the present study was to synthesize isoflavone-enaminones 3a-c and 7-alkoxy-isoflavones 4a-c , evaluate their inhibition of α-glucosidase,...
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Identification of herbal components as TRPA1 agonists and TRPM8 antagonists
Transient receptor potential (TRP) channels are non-selective cation channels that are implicated in analgesia, bowel motility, wound healing,...
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A DFT/TDDFT Investigation on Fluorescence and Electronic Properties of Chromone Derivatives
The development of quick and precise detection technologies for active compounds in vivo is critical for disease prevention, diagnosis and...
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Enhanced Oral Bioavailability of Isoformononetin Through Nanoemulsion: Development, Optimization, and Characterization
BackgroundIsoformononetin (IFN) is a methoxyl derivative of daidzein and has been stated as a potent osteogenic isoflavone. However, IFN has low oral...
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Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases
Plants and their derived phytochemicals have a long history of treating a wide range of illnesses for several decades. They are believed to be the...
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Daidzein Pro-cognitive Effects Coincided with Changes of Brain Neurotensin1 Receptor and Interleukin-10 Expression Levels in Obese Hamsters
At present, concerns are pointing to “tasteful” high-fat diets as a cause of conditioning physical-social states that through alterations of some key...
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Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice
RationaleCocaine addiction is a chronic relapsing disorder that lacks of an effective treatment. Isoflavones are a family of compounds present in...
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Subclinical carotid artery atherosclerosis and cognitive function in older adults
BackgroundThe combined effects of increased life expectancy and the considerable number of persons reaching old age will magnify the dementia...
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Genistein suppresses microglial activation and inhibits apoptosis in different brain regions of hypoxia-exposed mice model of amnesia
Genistein (GE) or 4′,5,7-trihydroxyflavone, a plant derived isoflavone, is a biologically active compound having several beneficial properties....
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Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential
Maclura tinctoria (Moraceae), commonly known as dinde, is a lactescent tree of significant economic importance with extensive ethnomedicinal and...
