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Unmet needs of drugs for irritable bowel syndrome and inflammatory bowel diseases: interest of vagus nerve stimulation and hypnosis
The gut and the brain communicate bidirectionally through the autonomic nervous system. The vagus nerve is a key component of this gut–brain axis,...
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Blood Serum Zonulin in Colorectal Cancer, Autoimmune Bowel Diseases, and Irritable Bowel Syndrome
Zonulin content in blood serum of patients with colorectal cancer (CRC; n =152; 30-84 years) and patients with large bowel adenomas ( n =32; 39-82...
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Association between irritable bowel syndrome and Parkinson’s disease by Cohort study and Mendelian randomization analysis
This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson’s disease (PD) utilizing prospective cohort...
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Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau
The gut microbiome shows changes under a plateau environment, while the disbalance of intestinal microbiota plays an important role in the...
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Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome
Interoceptive information relating to intestinal activity and environmental changes in the gut lumen is continuously and, generally, subconsciously...
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The Effect of Inflammatory Bowel Disease and Irritable Bowel Syndrome on Pravastatin Oral Bioavailability: In vivo and in silico evaluation using bottom-up wbPBPK modeling
The common disorders irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) can modify the drugs' pharmacokinetics via their induced...
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Irritable Bowel Syndrome
Irritable bowel syndrome is a chronic disorder associated with abdominal pain and altered bowel habits. The exact pathophysiology is not clearly...
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Evaluation of two laboratory model methods for diarrheal irritable bowel syndrome
BackgroundDiarrheal irritable bowel syndrome (IBS-D) is a common chronic functional gastrointestinal disorder, and the underlying pathogenic...
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Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
BackgroundIrritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study...
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The gut microbiota participates in the effect of linaclotide in patients with irritable bowel syndrome with constipation (IBS-C): a multicenter, prospective, pre-post study
BackgroundInterindividual variation characterizes the relief experienced by constipation-predominant irritable bowel syndrome (IBS-C) patients...
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Immune activation in irritable bowel syndrome: what is the evidence?
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder that is characterized by abdominal pain and an altered defecation...
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Multi-omics profiles of the intestinal microbiome in irritable bowel syndrome and its bowel habit subtypes
BackgroundIrritable bowel syndrome (IBS) is a common gastrointestinal disorder that is thought to involve alterations in the gut microbiome, but...
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Irritable Bowel Syndrome Associated with Blastocystis hominis or Without Relationship to It? A Case–Control Study and Minireview
BackgroundBlastocystis hominis ( B. hominis ) is a protozoan parasite that has a worldwide distribution. Some studies have suggested a link between B....
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Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data
BackgroundGut dysbacteriosis has been reported as one of the etiologies for irritable bowel syndrome (IBS). However, the association between gut...
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Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants
BackgroundIrritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied by mental conditions, including...
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Irritable bowel syndrome and microbiome; Switching from conventional diagnosis and therapies to personalized interventions
The human microbiome has been linked to several diseases. Gastrointestinal diseases are still one of the most prominent area of study in...
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Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome
Irritable bowel syndrome (IBS) is related to a problem in the gut-brain axis. This experimental research aimed to shed light on the potential...
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Enhancing Atorvastatin In Vivo Oral Bioavailability in the Presence of Inflammatory Bowel Disease and Irritable Bowel Syndrome Using Supercritical Fluid Technology Guided by wbPBPK Modeling in Rat and Human
Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are common disorders that can change the body’s physiology and drugs...
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Contribution of the Enteric Nervous System to Autoimmune Diseases and Irritable Bowel Syndrome
Anti-neuronal autoantibodies can lead to subacute gastrointestinal dysmotility, presenting with various symptoms typical of intestinal...
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Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement
BackgroundThere is growing recognition that bidirectional signaling between the digestive tract and the brain contributes to irritable bowel syndrome...
