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A current perspective on snake venom composition and constituent protein families
Snake venoms are heterogeneous mixtures of proteins and peptides used for prey subjugation. With modern proteomics there has been a rapid expansion...
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Annexin in Taenia crassiceps ORF Strain is Localized in the Osmoregulatory System
PurposeAnnexins are proteins with important roles in parasites, some of which are related to excretion–secretion processes, protein traffic, and...
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Bungarus fasciatus venom from eastern and north-east India: venom variation and immune cross-reactivity with Indian polyvalent antivenoms
Bungarus fasciatus is one of the medically important elapid snakes of South and South-eastern Asia and is responsible for several snakebite incidents...
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Systematic review and meta-analysis on the efficacy of Indian polyvalent antivenom against the Indian snakes of clinical significance
Snakebite in India is a severe problem as it causes a mortality rate of 58,000 and a disability rate of 140,000 every year which is the highest among...
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Local immune response of Canarian Majorera goats infected with Teladorsagia circumcincta
BackgroundDue to increased anthelmintic resistance, alternative methods to drugs are necessary to control gastrointestinal nematodes (GINs). Some of...
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1D-, 2D-Gel Electrophoresis, Immunoblotting, and Enzyme-Linked Immunosorbent Assay (ELISA) for the Study of Food Allergens
Protein-based methods have been fundamental for the study of food allergens, not only from a mechanistic and diagnostic point of view, but especially...
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Epithelial-Mesenchymal Plasticity: A Link Between Inflammation and Cancer Metastasis
Epithelial-mesenchymal plasticity (EMP) defines the ability of cells to transdifferentiate between epithelial and mesenchymal states. Tumor cells...
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Immunodiagnosis by Electrochemical Multiplexing in Clinical Samples
An essential part of current medical diagnosis is reliable multiplexed determination of clinical relevant biomarkers at different molecular level...
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Evolving landscape of PD-L2: bring new light to checkpoint immunotherapy
Immune checkpoint blockade therapy targeting programmed cell death protein 1 (PD-1) has revolutionized the landscape of multiple human cancer types,...
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Gene Therapy of Extracellular Vesicles in Cardiovascular and Metabolic Diseases
The ultimate and most complex form of treating human diseases is embodied by gene therapy. For an effective gene therapeutic product we need to hack...
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Ablation of Siglec-E augments brain inflammation and ischemic injury
Sialic acid immunoglobulin-like lectin E (Siglec-E) is a subtype of pattern recognition receptors found on the surface of myeloid cells and functions...
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Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its...
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Enhanced Sensitivity Rapid Tests for the Detection of Sepsis Marker Procalcitonin
Lateral flow immunoassay is a widely used method due to its simplicity and rapidity. However, insufficient sensitivity in the case of a biomarker...
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Conjugation of Meningococcal Lipooligosaccharides Through Their Non-Reducing Terminus Results in Improved Induction a Protective Immune Response
The present studies prove that conjugation of meningococcal lipooligosaccharides through their non-reducing terminus conserves their inner epitopes...
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Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model
Zika virus (ZIKV) is emerging as a significant pathogen worldwide and may cause severe neurological disorders such as fetal microcephaly and...
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The Immune Barrier: Influence of Food Components on the Intestinal Barrier
The skin and mucous membranes of the body constitute the first defense element of the immune system. Single- to multilayered epithelial end tissues...
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Increasing the sensitivity and accuracy of detecting exosomes as biomarkers for cancer monitoring using optical nanobiosensors
The advancement of nanoscience and material design in recent times has facilitated the creation of point-of-care devices for cancer diagnosis and...
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Localization of neurons expressing choline acetyltransferase, serotonin and/or FMRFamide in the central nervous system of the decapod shore crab Hemigrapsus sanguineus
Although it is now established that neurons in crustacea contain multiple transmitter substances, little is know about patterns of expression and...
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Association of HSPA1B genotypes with psychopathology and neurocognition in patients with the first episode of psychosis: a longitudinal 18-month follow-up study
Our aim was to analyze the association of HSPA1B genotypes and treatment response measured by the changes of psychopathology and neurocognitive...