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Modeling Orthopedic Injury and Its Impact: Biological Measures of Hypercoagulability and their Applications
Post-injury hypercoagulability is commonly seen in injured patients and is associated with an elevated risk of thromboembolic complications,...
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Modeling Orthopedic Injury and Its Impact: Biological Measures of Hypercoagulability and their Applications
Post-injury hypercoagulability is commonly seen in injured patients and is associated with an elevated risk of thromboembolic complications,...
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Novel characteristics of soluble fibrin: hypercoagulability and acceleration of blood sedimentation rate mediated by its generation of erythrocyte-linked fibers
Soluble fibrin (SF) in blood consists of monomers lacking both fibrinopeptides A with a minor population in multimeric clusters. It is a substantial...
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Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes
PurposeRecombinant human erythropoietin (rHuEPO) is known to increase thrombotic risk in patients and might have similar effects in athletes abusing...
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Diabetes and Cardiovascular Disorder
Diabetes mellitus especially type 2 diabetes mellitus (T2DM) is becoming more common at an alarming rate, resulting in increased disability,...
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The relationship between pancreatic cancer and hypercoagulability: a comprehensive review on epidemiological and biological issues
It has long been recognised that pancreatic cancer induces a hypercoagulable state that may lead to clinically apparent thrombosis. Although the...
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Understanding COVID-19-associated coagulopathy
COVID-19-associated coagulopathy (CAC) is a life-threatening complication of SARS-CoV-2 infection. However, the underlying cellular and molecular...
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Unraveling the enigma of long COVID: novel aspects in pathogenesis, diagnosis, and treatment protocols
Long COVID, now unmistakably identified as a syndromic entity encompassing a complex spectrum of symptoms, demands immediate resolution of its...
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HIV-associated multiple intracranial aneurysms and stroke in an adult patient: successful treatment with a combination of glucocorticoid and antiviral agents
A 35-year-old Iranian man with an 18-year history of human immunodeficiency virus (HIV) infection developed sudden left-sided hemiparesis and mild...
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Serum from COVID-19 patients promotes endothelial cell dysfunction through protease-activated receptor 2
BackgroundEndothelial dysfunction plays a central role in the pathophysiology of COVID-19 and is closely linked to the severity and mortality of the...
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Host-Derived Molecules as Novel Chagas Disease Biomarkers: Hypercoagulability Markers in Plasma
The most severe clinical symptomatology of Chagas disease affects ~30% of those chronically infected with the Trypanosoma cruzi parasite. The...
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The contact system in liver injury
Coagulation is controlled by a delicate balance of prothrombotic and antithrombotic mechanisms, to prevent both excessive blood loss from injured...
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Drug-Induced Blood Dyscrasias
Drug-induced hematological disorders though rare have long been an impending risk of modern pharmacotherapy. They can be life-threatening at times....
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Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps
BackgroundThe hypercoagulable state associated with pancreatic adenocarcinoma (PDA) results in increased risk of venous thromboembolism, leading to...
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Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options
Sleep-disordered breathing (SDB) can be a sequela of stroke caused by vascular injury to vital respiratory centers, cerebral edema, and increased...
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Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling
Venous thromboembolism (VTE) is a massive clinical challenge, annually affecting millions of patients globally. VTE is a particularly consequential...
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Elevated serum substance P during simian varicella virus infection in rhesus macaques: implications for chronic inflammation and adverse cerebrovascular events
Varicella and zoster, produced by varicella-zoster virus (VZV), are associated with an increased risk of stroke that may be due to persistent...
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