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Human Prion Disease Surveillance
Human prion diseases are characterized by rapid fatal neurodegeneration caused by pathologic prion proteins that are transmissible under specific...
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Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders
Human pluripotent stem cell (hPSC) models provide unprecedented opportunities to study human neurological disorders by recapitulating human-specific...
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Modeling Alzheimer’s Disease Using Human Brain Organoids
Alzheimer’s disease (AD) is the primary cause of dementia, to date. The urgent need to understand the biological and biochemical processes related to...
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Human iPSC-derived Disease Models for Drug Discovery
Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to...
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Deciphering Congenital Heart Disease Using Human Induced Pluripotent Stem Cells
Congenital heart disease (CHD) is a leading cause of birth defect-related death. Despite significant advances, the mechanisms underlying the...
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Resistome expansion in disease-associated human gut microbiomes
BackgroundThe resistome, the collection of antibiotic resistance genes (ARGs) in a microbiome, is increasingly recognised as relevant to the...
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Human antibody profiling technologies for autoimmune disease
Autoimmune diseases are caused by the break-down in self-tolerance mechanisms and can result in the generation of autoantibodies specific to human...
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The Spectrum of Tau Pathology in Human Prion Disease
Intracellular deposition of hyperphosphorylated tau characterizes tauopathies: there is a spectrum from neuron-predominant through mixed neuronal and...
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Animal Models for the Study of Human Disease
The use of conventional healthy animals (CHAs) has long been a mainstay of nonclinical safety testing as well as evaluation of efficacy of new...
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Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice
Human cerebral organoids (COs) are three-dimensional self-organizing cultures of cerebral brain tissue differentiated from induced pluripotent stem...
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Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
Microglia are central players in Alzheimer’s disease pathology but analyzing microglial states in human brain samples is challenging due to genetic...
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The Impact of Climate Change on Human Fungal Pathogen Distribution and Disease Incidence
Purpose of ReviewThis review aims to compile the current knowledge on the impact of climate change on human pathogenic fungi. Ongoing surveillance of...
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Structure-based network analysis predicts pathogenic variants in human proteins associated with inherited retinal disease
Advances in gene sequencing technologies have accelerated the identification of genetic variants, but better tools are needed to understand which are...
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Syncytin-1, syncytin-2 and suppressyn in human health and disease
In this review, we summarized the results of experimental and clinical studies about three human endogenous retroviruses and their...
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Chromatin modifiers in human disease: from functional roles to regulatory mechanisms
The field of transcriptional regulation has revealed the vital role of chromatin modifiers in human diseases from the beginning of functional...
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Interpreting non-coding disease-associated human variants using single-cell epigenomics
Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence variants in the human genome to common traits and diseases....
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Alzheimer’s Disease Methods and Protocols
This volume explores the latest techniques used to study the human brain towards understanding Alzheimer’s Disease and related neurodegenerative...
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Common mouse models of tauopathy reflect early but not late human disease
BackgroundMouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer’s Disease (AD) and...
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Prominent and conspicuous astrocyte atrophy in human sporadic and familial Alzheimer’s disease
Pathophysiology of sporadic Alzheimer’s disease (SAD) and familial Alzheimer’s disease (FAD) remains poorly known, including the exact role of...
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Bovine Paratuberculosis and Human Crohn’s Disease: Is There a Zoonotic Linkage?
Mycobacterium avium ssp. paratuberculosis (MAP) is an acid-fast bacterium, which causes paratuberculosis, an infectious enteric disease of ruminants,...