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Fasting-activated ventrolateral medulla neurons regulate T cell homing and suppress autoimmune disease in mice
Dietary fasting markedly influences the distribution and function of immune cells and exerts potent immunosuppressive effects. However, the...
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Homing tasks performed using variations of crawling gait patterns reveal a role for attention in podokinetic path integration
Self-motion can be perceived via podokinetic information, that is, based upon the movements of the legs during legged locomotion. This information...
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Ex Vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells
Cord blood (CB) has been proven to be an alternative source of haematopoietic stem cells (HSCs) for clinical transplantation and has multiple...
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Mobile group I introns at nuclear rDNA position L2066 harbor sense and antisense homing endonuclease genes intervened by spliceosomal introns
BackgroundMobile group I introns encode homing endonucleases that confer intron mobility initiated by a double-strand break in the intron-lacking...
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A unique eukaryotic lineage of composite-like DNA transposons encoding a DDD/E transposase and a His-Me finger homing endonuclease
BackgroundDNA transposons are ubiquitous components of eukaryotic genomes. A major group of them encode a DDD/E transposase and contain terminal...
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Homing tasks and distance matching tasks reveal different types of perceptual variables associated with perceiving self-motion during over-ground locomotion
Self-motion perception refers to the ability to perceive how the body is moving through the environment. Perception of self-motion has been shown to...
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Homing Peptides for Cancer Therapy
Tumor-homing peptides are widely used for improving tumor selectivity of anticancer drugs and imaging agents. The goal is to increase tumor uptake...
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The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα+ intraepithelial lymphocyte precursors
While T cell receptor (TCR) αβ + CD8α + CD8β – intraepithelial lymphocytes (CD8αα + IELs) differentiate from thymic IEL precursors (IELps) and contribute...
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Leukocyte Homing, Migration and Recirculation
Lymphocyte homing, trafficking and recirculation ensures maximum contact and interaction of cells with antigen, and correct homing of lymphocytes to...
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Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting
A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain....
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The Influence of Preconditioning on the Homing Behavior of Stem Cells
Stroke is the second leading cause of disability and death in the world. Therefore, there is an urgent need to develop treatment strategies for...
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Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system
CD4 + T helper 17 (T H 17) cells protect barrier tissues but also trigger autoimmunity. The mechanisms behind these opposing processes remain unclear....
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Associations of immune cell homing gene signatures and infiltrates of lymphocyte subsets in human melanomas: discordance with CD163+ myeloid cell infiltrates
BackgroundImmune cells in the tumor microenvironment have prognostic value. In preclinical models, recruitment and infiltration of these cells...
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Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
BackgroundImmune-mediated arthritis is a group of autoinflammatory diseases, where the patient’s own immune system attacks and destroys synovial...
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Assessing the relative contribution of vision to odometry via manipulations of gait in an over-ground homing task
The visual, vestibular, and haptic perceptual systems are each able to detect self-motion. Such information can be integrated during locomotion to...
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Hybridization of tumor homing and mitochondria-targeting peptide domains to design novel dual-imaging self-assembled peptide nanoparticles for theranostic applications
A novel hybridized dual-targeting peptide-based nanoprobe was successfully designed by using the cyclic heptapeptide. This peptide has...
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Cholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines
Dendritic cell (DC)-based cancer vaccines have so far achieved good therapeutic effects in animal experiments and early clinical trials for certain...
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The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs
Triple-negative breast cancer (TNBCs) display lung metastasis tropism. However, the mechanisms underlying this organ-specific pattern remains to be...
