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  1. Myosin Va-dependent Transport of NMDA Receptors in Hippocampal Neurons

    N-methyl-D-aspartate receptor (NMDAR) trafficking is a key process in the regulation of synaptic efficacy and brain function. However, the molecular...

    Ru Gong, Linwei Qin, ... Wei Lu in Neuroscience Bulletin
    Article Open access 30 January 2024
  2. TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury

    Background

    Neonatal hypoxia ischemia (HI) related brain injury is one of the major causes of learning disabilities and memory deficits in children. In...

    Vishal Chanana, Dila Zafer, ... Pelin Cengiz in Biology of Sex Differences
    Article Open access 02 April 2024
  3. Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information

    As a main structure of the limbic system, the hippocampus plays a critical role in pain perception and chronicity. The ventral hippocampal CA1 (vCA1)...

    Yue Wang, Naizheng Liu, ... You Wan in Neuroscience Bulletin
    Article Open access 13 July 2023
  4. Mitochondrial Calcium Waves by Electrical Stimulation in Cultured Hippocampal Neurons

    Mitochondria are critical to cellular Ca 2+ homeostasis via the sequestering of cytosolic Ca 2+ in the mitochondrial matrix. Mitochondrial Ca 2+ ...

    Yunkyung Eom, Sung Rae Kim, ... Sung Hoon Lee in Molecular Neurobiology
    Article 23 November 2023
  5. L-Type Calcium Channel Modulates Low-Intensity Pulsed Ultrasound-Induced Excitation in Cultured Hippocampal Neurons

    As a noninvasive technique, ultrasound stimulation is known to modulate neuronal activity both in vitro and in vivo . The latest explanation of this...

    Wen-Yong Fan, Yi-Ming Chen, ... Lei Xue in Neuroscience Bulletin
    Article 18 March 2024
  6. Deferoxamine Mitigates Ferroptosis and Inflammation in Hippocampal Neurons After Subarachnoid Hemorrhage by Activating the Nrf2/TXNRD1 Axis

    Ferroptosis is a distinct peroxidation-driven form of cell death tightly involved in subarachnoid hemorrhage (SAH). This study delved into the...

    Junting Hu, Meixiong Cheng, ... Qi Wang in Molecular Neurobiology
    Article 07 September 2023
  7. Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice

    Entorhinal cortical (EC)-hippocampal (HPC) circuits are crucial for learning and memory. Although it was traditionally believed that superficial...

    Naoki Yamamoto, Jun Yokose, ... Sachie K. Ogawa in Molecular Brain
    Article Open access 05 February 2024
  8. Analysis of Surface Expression of NMDAR Subunits in Primary Hippocampal Neurons

    The expression and activity of ionotropic glutamate receptors control signal transduction at the excitatory synapses in the CNS. The NMDAR comprises...
    Viktor Kuchtiak, Tereza Smejkalova, ... Ales Balik in NMDA Receptors
    Protocol 2024
  9. The Role and Mechanism of Ambra1-Mediated Mitophagy in TDCPP-Exposed Mouse Hippocampal Neurons

    Tri(1,3-dichloro-2-propyl)phosphate (TDCPP) is one of the most widely used organophosphorus flame retardants in consumer products. TDCPP has been...

    **aowei Zhang, Chuzhi Lin, ... Nengzhou Chen in Neurochemical Research
    Article 08 June 2024
  10. The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking

    The CC chemokine ligand 2 (CCL2, also known as MCP-1) and its cognate receptor CCR2 have well-characterized roles in chemotaxis. CCL2 has been...

    En Ji, Yuanyuan Zhang, ... Tian-Jia Song in Neuroscience Bulletin
    Article Open access 02 July 2024
  11. Ultrastructural Changes in Hippocampal Region CA1 Neurons After Exposure to Permissive Hypercapnia and/or Normobaric Hypoxia

    Isolated exposure to intermittent hypoxia and permissive hypercapnia activates signaling mechanisms that induce ultrastructural changes in...

    Pavel Tregub, Yuri Motin, ... Irada Ibrahimli in Cellular and Molecular Neurobiology
    Article 16 September 2023
  12. Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons

    During the establishment of neuronal circuits, axons and dendrites grow and branch to establish specific synaptic connections. This complex process...

    M. Diez-Zaera, A. Ruiz-Calvo, ... M. T. Miras-Portugal in Purinergic Signalling
    Article Open access 29 May 2023
  13. Ketamine exerts dual effects on the apoptosis of primary cultured hippocampal neurons from fetal rats in vitro

    Ketamine, a noncompetitive N-methyl D-aspartate (NMDA) receptor antagonist, is widely used in pediatric clinical practice. The neuroprotective and...

    Guo-Hua Wu, Que-Hui Guo, ... Liang-Cheng Zhang in Metabolic Brain Disease
    Article 05 June 2023
  14. Doxycycline reversal of amphetamine-induced mania-like behavior is related to adjusting brain monoamine abnormalities and antioxidant effects in primary hippocampal neurons

    Mania is associated with disturbed dopaminergic transmission in frontotemporal regions. D-amphetamine (AMPH) causes increased extracellular DA...

    Adriano José Maia Chaves-Filho, Michele Verde-Ramo Soares, ... Danielle S. Macedo in Naunyn-Schmiedeberg's Archives of Pharmacology
    Article 22 February 2024
  15. Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K/Akt/GSK-3β signaling pathway

    Background

    Diabetic encephalopathy is manifested by cognitive dysfunction. Salidroside, a nature compound isolated from Rhodiola rosea L , has the...

    Xue-Hua Wang, Zhong-Fu Zuo, ... De-Yu Zheng in Psychopharmacology
    Article 25 July 2023
  16. Resident Astrocytes can Limit Injury to Develo** Hippocampal Neurons upon THC Exposure

    Cannabis legalization prompted the dilemma if plant-derived recreational drugs can have therapeutic potential and, consequently, how to address their...

    Maria Krassnitzer, Brooke Boisvert, ... Erik Keimpema in Neurochemical Research
    Article Open access 08 December 2022
  17. The Effect of Intranasal Administration of Gangliosides on the Viability of CA1 Hippocampal Neurons in Rat Two-Vessel Occlusion Model of Forebrain Ischemia/Reperfusion Injury

    Intranasal administration of total bovine brain gangliosides (6 mg/kg) to rats protected the CA1 hippocampal neurons from the death caused by...

    D. K. Avrova, L. V. Bayunova, ... I. O. Zakharova in Bulletin of Experimental Biology and Medicine
    Article 01 April 2024
  18. G-CSF improved the memory and dendritic morphology impairments in the hippocampal CA1 pyramidal neurons after brain ischemia in the male rats

    Background

    Stroke remains the leading cause of death and disability in the world. A new potential treatment for stroke is the granulocyte...

    Hamzeh Badeli Sarkala, Mehrdad Jahanshahi, ... Mohammad Reza Namavar in Metabolic Brain Disease
    Article 20 September 2023
  19. Genetic Knockout of TRPM2 Increases Neuronal Excitability of Hippocampal Neurons by Inhibiting Kv7 Channel in Epilepsy

    Epilepsy is a chronic brain disease that makes serious cognitive and motor retardation. Ion channels affect the occurrence of epilepsy in various...

    Yingchao Ying, Lifen Gong, ... Peifang Jiang in Molecular Neurobiology
    Article 02 September 2022
  20. Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons

    Our understanding of the biological functions of the tau protein now includes its role as a scaffolding protein involved in signaling regulation,...

    Kyle R. Christensen, Benjamin Combs, ... Nicholas M. Kanaan in Molecular Neurobiology
    Article 02 March 2023
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