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X-linked genes exhibit miR6891-5p-regulated skewing in Sjögren’s syndrome
AbstractMany autoimmune diseases exhibit a strikingly increased prevalence in females, with primary Sjögren’s syndrome (pSS) being the most...
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Ability of a selfish B chromosome to evade genome elimination in the jewel wasp, Nasonia vitripennis
B chromosomes are non-essential, extra chromosomes that can exhibit transmission-enhancing behaviors, including meiotic drive, mitotic drive, and...
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Live Cell Imaging of Nuclear Actin Filaments and Heterochromatic Repair foci in Drosophila and Mouse Cells
Pericentromeric heterochromatin is mostly composed of repeated DNA sequences, which are prone to aberrant recombination during double-strand break...
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Evidence of accelerated epigenetic aging of breast tissues in patients with breast cancer is driven by CpGs associated with polycomb-related genes
PurposeAge is one of the strongest risk factors for the development of breast cancer, however, the underlying etiology linking age and breast cancer...
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Epigenetics
Epigenetics is the study of heritable changes to the genome and gene expression patterns that are not caused by direct changes to the DNA sequence....
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Sex Chromosome Haploty**
Chromosomes X and Y have been true homologues and have evolved differently over the years. The Y chromosome has shrunk to about 60 Mb in size as a...
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The conne**on between sex and immune responses
There are notable sex-based differences in immune responses to pathogens and self-antigens, with female individuals exhibiting increased...
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Genes and Chromatin
In this introductory chapter, principles of gene expression are discussed, which will be explored in following chapters in more detail. The human...
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Gene-poor Y-chromosomes substantially impact male trait heritabilities and may help shape sexually dimorphic evolution
How natural selection facilitates sexually dimorphic evolution despite a shared genome is unclear. The patrilineal inheritance of Y-chromosomes makes...
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MicroRNAs in Cancer: Diagnostics and Therapeutics
Tumor initiation, recurrence, progression, and spread of cancer are multistep processes which involve numerous molecular and cellular mechanisms. One...
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Epigenetic Regulation of Fungal Secondary Metabolites for the Enhancement of Therapeutically Active Compounds
The microbial flora has always been a center of interest for the identification of novel bioactive secondary metabolites (SMs) used against a...
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Heteromorphismes: Mutations in Non-Coding-DNA Regions
For a long time, the constitutive heterochromatin has been regarded as neglectable as to its significance of mutations in chromosome structure and...
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LINE-1 transcription activates long-range gene expression
Long interspersed nuclear element-1 (LINE-1 or L1) is a retrotransposon group that constitutes 17% of the human genome and shows variable expression...
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Cancer Epigenetics
Epigenetic mechanisms establish cell type-specific gene expression patterns that are stably transmitted across cell divisions. Epigenetic changes in...
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A systematic screen for co-option of transposable elements across the fungal kingdom
How novel protein functions are acquired is a central question in molecular biology. Key paths to novelty include gene duplications, recombination or...
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MicroRNAs in Cancer: Diagnostics and Therapeutics
Tumor initiation, recurrence, progression, and spread of cancer are multistep processes which involve numerous molecular and cellular mechanisms. One...
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Histone 3.3-related chromatinopathy: missense variants throughout H3-3A and H3-3B cause a range of functional consequences across species
There has been considerable recent interest in the role that germline variants in histone genes play in Mendelian syndromes. Specifically, missense...
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Aging and Cancer
In this chapter, we will discuss aging as the progressive decline in the function of cells, tissues and organs that leads to impaired functions of...
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Gene Expression and Chromatin
In this chapter, principles of gene expression are discussed. An essential condition that a gene can be expressed, i.e., transcribed into RNA, is...