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Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect
Cardiac glycosides, known as inhibitors of Na + ,K + -ATPase, have anti-cancer effects such as suppression of cancer cell proliferation and induction of...
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The potential link between acromegaly and risk of acute ischemic stroke in patients with pituitary adenoma: a new perspective
Acromegaly is an endocrine disorder due to the excess production of growth hormone (GH) from the anterior pituitary gland after closed epiphyseal...
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Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma
BackgroundColorectal cancer (CRC), ranking third in cancer prevalence and second in mortality worldwide, is mainly derived from colorectal adenoma...
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Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop
Hepatocellular carcinoma (HCC) is associated with a poor prognosis. Our previous study demonstrated that Pleomorphic adenoma gene like-2 (PLAGL2) was...
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A circulating cell-free DNA methylation signature for the detection of hepatocellular carcinoma
To address the shortcomings of current hepatocellular carcinoma (HCC) surveillance tests, we set out to find HCC-specific methylation markers and...
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Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
Triclosan is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its...
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Hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas complicating familial adenomatous polyposis: two cases and review of the literature
Familial adenomatous polyposis (FAP) is characterized by colorectal polyposis and extracolonic tumors. Adenocarcinoma of the pancreas and...
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Prevalence of metabolic syndrome among patients with hepatocellular carcinoma of different etiologies: a retrospective study
AimsThis study compared the prevalences of metabolic syndrome and of cardiac or kidney comorbidities among patients with hepatocellular carcinoma...
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PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib induced ferroptosis through a PVT1/miR-195-5p axis-dependent manner in hepatocellular carcinoma
BackgroundSorafenib is a standard first-line treatment for advanced hepatocellular carcinoma (HCC), yet its effectiveness is often constrained....
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Development and validation of a selenium metabolism regulators associated prognostic model for hepatocellular carcinoma
BackgroundSelenium metabolism has been implicated in human health. This study aimed to identify a selenium metabolism regulator-based prognostic...
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Non-invasive diagnosis strategy of hepatocellular carcinoma in low-risk population
AimsWith prevalence of hepatocellular carcinoma (HCC) in low-risk population (LRP), establishing a non-invasive diagnostic strategy becomes...
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Saroglitazar suppresses the hepatocellular carcinoma induced by intraperitoneal injection of diethylnitrosamine in C57BL/6 mice fed on choline deficient, l-amino acid- defined, high-fat diet
BackgroundSaroglitazar is a novel PPAR-α/γ agonist with predominant PPAR-α activity. In various preclinical models, saroglitazar has been shown to...
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Research on multi-model imaging machine learning for distinguishing early hepatocellular carcinoma
ObjectiveTo investigate the value of differential diagnosis of hepatocellular carcinoma (HCC) and non-hepatocellular carcinoma (non-HCC) based on CT...
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TRIM proteins in hepatocellular carcinoma
The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a...
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Diethylnitrosamine-Induced Liver Tumorigenesis in Mice Under High-Hat High-Sucrose Diet: Stepwise High-Resolution Ultrasound Imaging and Histopathological Correlations
The hepatotoxic N-nitroso compound diethylnitrosamine (DEN) administered intraperitoneally (i.p.) induces liver neoplasms in rodents that...
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Low expression of the dynamic network markers FOS/JUN in pre-deteriorated epithelial cells is associated with the progression of colorectal adenoma to carcinoma
BackgroundDeterioration of normal intestinal epithelial cells is crucial for colorectal tumorigenesis. However, the process of epithelial cell...
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Hypoxia signaling in hepatocellular carcinoma: Challenges and therapeutic opportunities
Hepatocellular carcinoma (HCC) is one of the most common cancers with a relatively high cancer-related mortality. The uncontrolled proliferation of...
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Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma
BackgroundInvasive malignant pleomorphic adenoma (IMPA) is a highly malignant neoplasm of the oral salivary glands with a poor prognosis and a...
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Statin use is associated with the reduction in hepatocellular carcinoma recurrence after liver surgery
BackgroundHepatocellular carcinoma (HCC) is the sixth most common form of cancer worldwide. Although surgical treatments have an acceptable cure...
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Liver cancer stem cell dissemination and metastasis: uncovering the role of NRCAM in hepatocellular carcinoma
BackgroundLiver cancer stem cells (LCSCs) play an important role in hepatocellular carcinoma (HCC), but the mechanisms that link LCSCs to HCC...
