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Dalayed Effects of Antitumor Drug Paclitaxel on the Hereditary Material and Hemopoietic System of CBA Mice
Paclitaxel in a single MTD of 40 mg/kg caused chromosome aberrations and genome changes (polyploidy) in the bone marrow cells of mice early and 3...
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Post-exposure prophylaxis with sotrovimab for Omicron (B.1.1.529) SARS-CoV-2 variant during the aplastic phase of autologous stem cell transplantation
BackgroundTo date, there is no information on the safety and efficacy of the novel anti-sarbecoviruses monoclonal antibody sotrovimab administered,...
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Involvement of Signaling Cascades in Granulocytopoiesis Regulation under Conditions of Cytostatic Treatment
Suppression of the production of granulocytic CSF under the effect of 5-fluorouracyl is related to disorders in the NF-κB-, cAMP-dependent signaling...
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ROS and Redox Regulation/Signaling and Metabolism in Cancer Stem Cells
In this chapter entitled “ROS and Redox Regulation/Signaling and Metabolism in Cancer Stem Cells,” first the concept of “normal stem cells” and...
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The Role of Intracellular Signaling Molecules in the Production of Granulocytic CSF Mononuclear Phagocytes in Stress and Cytostatic Influence
Under conditions of steady-state hemopoiesis, nuclear factor NF-κB, in contrast to MAP kinase p38, plays an important role in the maintenance of the...
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Immune compartments at the brain’s borders in health and neurovascular diseases
Recent evidence implicates cranial border immune compartments in the meninges, choroid plexus, circumventricular organs, and skull bone marrow in...
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Osteogenic Commitment of MSC Is Enhanced after Interaction with Umbilical Cord Blood Mononuclear Cells In Vitro
The effectiveness of stroma-dependent expansion of hematopoietic cells ex vivo may depend on the level of commitment of multipotent mesenchymal...
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Oxygen Level Modifies the Expression of Genes Involved in the Epigenetic Regulation of Multipotent Stromal Cells In Vitro
Changes in the transcriptional activity of genes involved in the epigenetic regulation of adipose tissue multipotent mesenchymal stromal cells were...
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Effects of Bone Marrow Autotransplantation on the Bone Marrow Neurotransmitter Structures
Morphological structures involved in local regulation of tissue processes and the neurotransmitters they produce are assumed to play an important...
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Myeloid-derived suppressor cells: key immunosuppressive regulators and therapeutic targets in hematological malignancies
The immunosuppressive tumor microenvironment (TME) supports the development of tumors and limits tumor immunotherapy, including hematological...
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Dynamics of Changes in the Properties of Multipotent Mesenchymal Stromal Cells in Patients with Acute Leukemia
In acute leukemia, the stromal microenvironment of the bone marrow that regulates hematopoiesis is modified under the influence of malignant cells....
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A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans
A network of co-hepato/pancreatic stem/progenitors exists in pigs and humans in Brunner’s Glands in the submucosa of the duodenum, in peribiliary...
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Cells of the Central Nervous System: An Overview of Their Structure and Function
The central nervous system is the last major organ system in the vertebrate body to yield its cellular structure, due to the complexity of its cells...
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Metabolic Disorders and Mineral Density of the Bone Tissue in the Early Pathogenesis of Osteonecrosis: Study on Rabbits with Steroid-Induced Osteonecrosis
The relationship between the appearance of bone metabolism disorders and the onset of steroid-induced osteonecrosis remains unclear. We studied the...
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Detection and Isolation of Cancer Stem Cells
The discovery and isolation of the hematopoietic stem cell (HSC) from bone marrow grafts introduced the concept of a cell type capable of restoring...
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Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia
Ischemic stroke is a major cause of death and disability worldwide. Translation into the clinical setting of neuroprotective agents showing promising...
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Hemostimulating Effects of c-Jun N-Terminal Kinase (JNK) Inhibitor during Cytostatic Myelosuppression and Mechanisms of Their Development
The hemostimulating effects of c-Jun N-terminal kinase (JNK) inhibitor were examined on the mouse model of myelosuppression provoked by...
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Responses of Blood System to Doxorubicin/Docetaxel Chemotherapy in Patients with Breast Cancer
We studied the effects of combined chemotherapy with doxorubicin/docetaxel on erythroid and granulocytic hematopoietic lineages with particular...
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Role of Angiogenesis in Tumors
Cancer is one of the deadly diseases marked by the uncontrolled proliferation and accumulation of abnormal cancer cells. The incidence of cancer and...
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Changes in Bone Marrow Stromal Progenitor Cells in Patients with Hematoblastosis at the Onset of the Disease
Multipotent mesenchymal stromal cells (MSC) are the key regulators of hematopoiesis. We studied changes in MSC characteristics in patients with...