Search
Search Results
-
Inhibitory effects of N-methyl-D-aspartate (NMDA) and α1-adrenergic receptor antagonist ifenprodil on human Kv1.5 channel
Ifenprodil has been known to reduce cardiac contractility and cerebral vasodilation by antagonizing α 1 -adrenergic and N-methyl D-aspartate...
-
Cardiac optogenetics: shining light on signaling pathways
In the early 2000s, the field of neuroscience experienced a groundbreaking transformation with the advent of optogenetics. This innovative technique...
-
Stability of N-type inactivation and the coupling between N-type and C-type inactivation in the Aplysia Kv1 channel
The voltage-dependent potassium channels (Kv channels) show several different types of inactivation. N-type inactivation is a fast inactivating...
-
Regulation of human cardiac Kv1.5 channels by extracellular acidification
Human Kv1.5 channels (hKv1.5) conduct the ultra-rapid delayed rectifier potassium current ( I Kur ), which plays an important role in action potential...
-
Patch-Clamp and Voltage-Clamp Techniques
The introduction of the patch-clamp technique (Neher and Sakmann 1976) revolutionized the study of cellular physiology by providing a high-resolution...
-
Sumo Modification of Ion Channels
Recently, a role for SUMO modification outside of the nucleus has emerged. Although the number of extranuclear proteins known to be sumoylated is...
-
The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
We examined the inhibitory effect of amiodarone, a class III anti-arrhythmic agent, on voltage-dependent K + (Kv) currents in freshly isolated rabbit...
-
Patch-Clamp and Voltage-Clamp Techniques
The introduction of the patch-clamp technique (Neher and Sakmann 1976) revolutionized the study of cellular physiology by providing a high-resolution...
-
Label-Free Cell-Based Biosensor Methods in Drug Toxicology Analysis
Cell-based biosensors are one kind of devices that employ immobilized living cells as sensing elements combined with sensors or transducers to detect...
-
Conservation analysis of residues in the S4–S5 linker and the terminal part of the S5-P-S6 pore modulus in Kv and HCN channels: flexible determinants for the electromechanical coupling
Protein mobility is important to achieve protein function. Intrinsic flexibility associated with motion underlies this important issue and the...
-
Comparison of the effects of antiarrhythmic drugs flecainide and verapamil on fKv1.4ΔN channel currents in Xenopus oocytes
Aim:To study the effects of Na + channel blocker flecainide and L-type Ca 2+ channel antagonist verapamil on the voltage-gated fKv1.4ΔN channel, an...
-
The angiotensin receptor blocker and PPAR-γ agonist, telmisartan, delays inactivation of voltage-gated sodium channel in rat heart: novel mechanism of drug action
Telmisartan is an angiotensin II receptor blocker and partial peroxisome proliferator-activated receptor gamma agonist that modulates the...
-
Effects of the novel amiodarone-like compound SAR114646A on cardiac ion channels and ventricular arrhythmias in rats
Amiodarone is the "gold standard" for current antiarrhythmic therapy because it combines efficacy with good hemodynamic and electrophysiological...
-
The Role of Nitric Oxide in the Regulation of Ion Channels in the Cardiomyocytes: Link to Mechanically Gated Channels
This review is devoted to the role of nitric oxide in the regulation of ion channels in the cardiomyocytes. Here we consider issues of regulation of...
-
Effects of diltiazem and propafenone on the inactivation and recovery kinetics of fKv1.4 channel currents expressed in Xenopus oocytes
Aim:To investigate the effects of diltiazem, an L-type calcium channel blocker, and propafenone, a sodium channel blocker, on the inactivation and...
-
Electropharmacological properties of telmisartan in blocking hKv1.5 and HERG potassium channels expressed on Xenopus laevis oocytes
Aim:The objectives of this study were to investigate the inhibitory action of telmisartan, a selective angiotensin II type 1 receptor antagonist, on...
-
Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of I Ks current in guinea pig atrium
A repolarizing conduction in the heart augmented by hyposmotic or mechanically induced membrane stretch is the slow component of delayed rectifier K + ...
