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  1. Gout

    in Dictionary of Toxicology
    Reference work entry 2024

  2. Upregulation of CD39 During Gout Attacks Promotes Spontaneous Remission of Acute Gouty Inflammation

    Gout is a self-limiting form of inflammatory arthropathy caused by the formation of urate crystals due to hyperuricemia. The resolution of gout...

    Chengyu Luo, **ngyue Liu, ... **hui Tao in Inflammation
    Article 06 December 2023

  3. Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway

    Background

    Gout pain seriously affects the quality of patients' life. There is still no effective treatment. The inflammatory response is the main...

    Wen Fan, Chong Liu, ... Liang Hu in Journal of Translational Medicine
    Article Open access 08 December 2023

  4. Peripheral T Cell Populations are Differentially Affected in Familial Mediterranean Fever, Chronic Granulomatous Disease, and Gout

    Both innate errors of immunity, such as familial Mediterranean fever (FMF) and chronic granulomatous disease (CGD), and the common inflammatory...

    Burcu Al, Mariolina Bruno, ... Katarzyna Placek in Journal of Clinical Immunology
    Article Open access 16 September 2023

  5. Hyperuricemia and gout increased the risk of long-term mortality in patients with heart failure: insights from the National Health and Nutrition Examination Survey

    Background

    The prevalence of hyperuricemia, gout, and heart failure (HF) is on the rise, and these conditions often share similar risk factors. The...

    Yingdong Han, Yu Cao, ... Xuejun Zeng in Journal of Translational Medicine
    Article Open access 12 July 2023

  6. Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study

    Objectives

    The association between habitual glucosamine use and incident gout has not been examined in previous studies. We aimed to evaluate the...

    Mengyi Liu, Ziliang Ye, ... **anhui Qin in Biology of Sex Differences
    Article Open access 30 September 2022

  7. Dose-response meta-analysis on urate, gout, and the risk for Parkinson’s disease

    The relationship between Parkinson’s disease (PD) and urate or gout has attracted significant interest in recent years, but the results were...

    Hongtao Chang, Benqiao Wang, ... Ruixia Zhu in npj Parkinson's Disease
    Article Open access 22 November 2022

  8. Angiotensin type 2 receptor antagonism as a new target to manage gout

    Background

    There is a growing search for therapeutic targets in the treatment of gout. The present study aimed to evaluate the analgesic and...

    Thiago Neves Vieira, André L. Lopes Saraiva, ... Cassia Regina Silva in Inflammopharmacology
    Article 29 September 2022

  9. CT image findings of spinal gout

    Background

    Spinal gout is uncommon. The clinical manifestations of spinal gout are not characteristic. Huge tophi can invade the vertebral joints and...

    Yuling Yang, Yongfei Guo, ... Bin Zou in Spinal Cord
    Article 17 February 2022

  10. RETRACTED ARTICLE: Transdermal delivery of allopurinol-loaded nanostructured lipid carrier in the treatment of gout

    Background

    Allopurinol (ALP), a xanthine oxidase inhibitor, is a first line drug for the treatment of gout and hyperuricemia. Being the member of BCS...

    Zakir Ali, Fakhar ud Din, ... Gul Majid Khan in BMC Pharmacology and Toxicology
    Article Open access 28 November 2022

  11. Enhancing the Response Rate to Recombinant Uricases in Patients with Gout

    Refractory, or uncontrolled, gout is a chronic, progressive, inflammatory arthropathy resulting from continued urate deposition after failed attempts...

    Naomi Schlesinger, Lissa Padnick-Silver, Brian LaMoreaux in BioDrugs
    Article Open access 22 March 2022

  12. Pharmacotherapy of Gout

    Gout is characterized by painful joint inflammation due to the deposition of monosodium urate (MSU) crystals as a result of hyperuricemia. The...
    Ilanthamizhan Jayakumar in Introduction to Basics of Pharmacology and Toxicology
    Chapter 2021

  13. Taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism

    Objective

    To evaluate the taxonomic composition of the gut microbiome in gout patients with and without tophi formation, and predict bacterial...

    Eder Orlando Méndez-Salazar, Janitzia Vázquez-Mellado, ... Gabriela Angélica Martínez-Nava in Molecular Medicine
    Article Open access 24 May 2021

  14. Genetic correlations between traits associated with hyperuricemia, gout, and comorbidities

    Hypertension, obesity, chronic kidney disease and type 2 diabetes are comorbidities that have very high prevalence among persons with hyperuricemia...

    Richard J. Reynolds, M. Ryan Irvin, ... Ana I. Vazquez in European Journal of Human Genetics
    Article 26 February 2021

  15. Evaluation of the causal effects of blood lipid levels on gout with summary level GWAS data: two-sample Mendelian randomization and mediation analysis

    Observational studies have identified gout patients are often comorbid with dyslipidemia. However, the relationship between dyslipidemia and gout is...

    **nghao Yu, Ting Wang, ... ** Zeng in Journal of Human Genetics
    Article 25 October 2020

  16. Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways

    Monosodium urate (MSU) crystals, the etiological agent of gout, are formed in joints and periarticular tissues due to long-lasting hyperuricemia....

    Chun-su Zhong, Bo Zeng, ... **an-hui He in Acta Pharmacologica Sinica
    Article 10 August 2021

  17. Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages

    Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the...

    Chun-Ying Qiao, Ying Li, ... Li-Hua Lian in Inflammopharmacology
    Article 01 October 2020

  20. Better outcomes for patients with gout

    Gout is increasing in prevalence despite effective pharmacotherapies. Barriers to effective management are largely educational deficiencies....

    Richard Day, Amy Nguyen, ... Sophie Stocker in Inflammopharmacology
    Article 25 February 2020
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