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Glutathione S-transferase M1 and T1 genes deletion polymorphisms and blood pressure control among treated essential hypertensive patients in Burkina Faso
ObjectiveGlutathione S-transferases have been associated with experimental resistance to some drugs. The present study investigated the factors...
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Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of develo** essential hypertension: a case-control study in Burkina Faso population (West Africa)
BackgroundGlutathione S-transferases play a key role in the detoxification of persistent oxidative stress products which are one of several risks...
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Acetylcholinesterase, Butyrylcholinesterase and Glutathione S-Transferase Enzyme Activities and Their Correlation with Genotypic Variations Based on GST M1 and GST T1 Loci in Long Term-Pesticide-Exposed Tea Garden Workers of Sub-Himalayan West Bengal
ObjectiveOrganophosphates (OPs) and carbamates (CBs) are known to reduce acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and increase...
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An inside out journey: biogenesis, ultrastructure and proteomic characterisation of the ectoparasitic flatworm Sparicotyle chrysophrii extracellular vesicles
BackgroundHelminth extracellular vesicles (EVs) are known to have a three-way communication function among parasitic helminths, their host and the...
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Anthelmintic and Hepatoprotective Activities of the Green-Synthesized Zinc Oxide Nanoparticles Against Parascaris equorum Infection in Rats
Main conclusionsGreen-synthesized zinc oxide nanoparticle is a promising treatment modality against parasitic infection through its powerful...
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SHARPIN contributes to sevoflurane-induced neonatal neurotoxicity through up-regulating HMGB1 to repress M2 like-macrophage polarization
Sevoflurane exposure can result in neurotoxicity especially among children, which remains an important complication after surgery. However, its...
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Susceptibility of Polymorphic GST as a Risk Factor in Oxidative Stress-Induced Cancer Development
Cancer is the leading cause of mortality and morbidity with oxidative stress playing an important role in the development of cancer....
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Susceptibility of Polymorphic GST as a Risk Factor in Oxidative Stress-Induced Cancer Development
Cancer is the leading cause of mortality and morbidity with oxidative stress playing an important role in the development of cancer....
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Pharmacological evaluation of newly synthesized organotin IV complex for antiulcer potential
The present study aims to investigate the newly synthesized organotin (IV) complex (2E, 2′E) dibutylstannanediyl bis (4-(4-nitrophenyl)...
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Synergistic effect of YOD1 and USP21 on the Hippo signaling pathway
BackgroundDeubiquitinating enzymes (DUBs) comprise a family of proteases responsible for cleaving the peptide or isopeptide bond between ubiquitin...
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Therapeutic Implication of Oxidative Stress Regulators in Drug-Resistant Cancers
Although initial clinical responses to current standard chemotherapies are often dramatic, a significant number of cancer patients develop drug...
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Pharmacogenomics and Cancer Treatment
Somatic and germline genetic variations are two types of interindividual variations affecting drug response in cancer treatment. Pharmacogenomics...
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Exosomal let-7a-5p derived from human umbilical cord mesenchymal stem cells alleviates coxsackievirus B3-induced cardiomyocyte ferroptosis via the SMAD2/ZFP36 signal axis
Viral myocarditis (VMC) is one of the most common acquired heart diseases in children and teenagers. However, its pathogenesis is still unclear, and...
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Therapeutic Implication of Oxidative Stress Regulators in Drug-Resistant Cancers
Although initial clinical responses to current standard chemotherapies are often dramatic, a significant number of cancer patients develop drug...
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Antioxidant and Anti-Inflammatory Activity of 4-Hexylresorcinol
This chapter discusses the role of 4HR ointment in dental injury treatment and its potential to reduce oxidative stress and inflammation. Dental...
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Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS
Aflatoxin B 1 (AFB 1 ) is a highly hepatotoxic and carcinogenic mycotoxin produced by Aspergillus species. The compound is mainly metabolized in the...
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Why is Babesia not killed by artemisinin like Plasmodium?
Babesia spp. are intraerythrocytic apicomplexans that digest and utilize red blood cells in a similar way to intraerythrocytic Plasmodium spp., but...
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The Role of Iron Metabolism, Lipid Metabolism, and Redox Homeostasis in Alzheimer’s Disease: from the Perspective of Ferroptosis
In the development of Alzheimer’s disease (AD), cell death is common. Novel cell death form—ferroptosis is discovered in recent years. Ferroptosis is...
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Glutathione in Chlorpyrifos-and Chlorpyrifos-Oxon-Induced Toxicity: a Comparative Study Focused on Non-cholinergic Toxicity in HT22 Cells
Chlorpyrifos (CPF) is a neurotoxic organophosphorus (OP) insecticide widely used for agricultural purposes. CPF-mediated neurotoxicity is mainly...
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Diagnostic Biomarkers of Urinary Bladder Cancer and Their Applications: An Update
Bladder cancer, also known as Urinary bladder cancer (UBC) is one of the most prevalent cancer of layers of bladder. The most recent GLOBOCAN...