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Gene function annotations for the maize NAM founder lines
ObjectivesWe annotated the latest published sequences of the 26 Zea mays Nested Association Map** (NAM) founder lines using GOMAP, the Gene...
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Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import
Organisms maintain metabolic homeostasis through the combined functions of small-molecule transporters and enzymes. While many metabolic components...
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Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function
DNA methylation (DNAm) changes play a key role in regulating gene expression in asthma. To investigate the role of epigenetics and transcriptomics...
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Nanodelivery in Gene Therapy
Gene therapy stands as a revolutionary approach in medicine, aiming to rectify genetic abnormalities by introducing therapeutic genes or regulating...
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Rapid Testing of Gene Function in Axonal Regeneration After Spinal Cord Injury Using Larval Zebrafish
Larval zebrafish show axonal regrowth over a complex spinal injury site and recovery of function within days after injury. Here we describe a simple...
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ApoE gene polymorphisms and metals and their interactions with cognitive function
ObjectiveTo analyze the relationship between plasma metal elements, ApoE gene polymorphisms and the interaction between the two and impaired...
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Machine Learning Using Gene-Sets to Infer miRNA Function
miRNA are regulators of cell phenotype, and there is clear evidence that these small posttranscriptional modifiers of gene expression are involved in...
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Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis
Genes involved in synaptic function are enriched among those with autism spectrum disorder (ASD)-associated rare genetic variants. Dysregulated...
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Pendrin abundance, subcellular distribution, and function are unaffected by either αENaC gene ablation or by increasing ENaC channel activity
The intercalated cell Cl − /HCO 3 − exchanger, pendrin, modulates ENaC subunit abundance and function. Whether ENaC modulates pendrin abundance and...
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Revealing gene function with statistical inference at single-cell resolution
Single-cell and spatial molecular profiling assays have shown large gains in sensitivity, resolution and throughput. Applying these technologies to...
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Virus-Induced Heritable Gene Editing in Plants
Gene editing using clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) nuclease is an excellent tool for...
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Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A -rearranged ( KMT2A-r ) acute myeloid...
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Lactylation: the novel histone modification influence on gene expression, protein function, and disease
Lactic acid, traditionally considered as a metabolic waste product arising from glycolysis, has undergone a resurgence in scientific interest since...
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Knock-out of 5-lipoxygenase in overexpressing tumor cells—consequences on gene expression and cellular function
5-Lipoxygenase (5-LO), the central enzyme in the biosynthesis of leukotrienes, is frequently expressed in human solid malignancies even though the...
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Comprehensive analysis of the function of helicobacter-associated ferroptosis gene YWHAE in gastric cancer through multi-omics integration, molecular docking, and machine learning
Gastric cancer is strongly associated with Helicobacter pylori ( H . pylori ) infection. However, the molecular mechanisms underlying the development of...
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Immune Gene Therapy of Cancer
Cancer is the second global cause of mortality. Conventional treatments, such as chemotherapy and radiotherapy, have not provided desirable...
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Association of MPPED2 gene variant rs10767873 with kidney function and risk of cardiovascular disease in patients with hypertension
Changes in kidney function and the progression of chronic kidney disease (CKD) are associated with the risk of cardiovascular disease (CVD) and...
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Expression and Function of MAO A in Cardiac Cells by Means of Adenovirus-Mediated Gene Transfer
Gene-transfer methods are useful to study the structural or functional roles of recombinant proteins in vitro. In particular, adenovirus-mediated...
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Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels
The blood–brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are...
