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Gene–Nutrient Interaction and Cancer Prevention
Research on carcinogenesis has provided a plethora of knowledge regarding cancer. Cancer cells are the product of numerous genetic abnormalities that...
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Gene–Nutrient Interaction and Cancer Prevention
Research on carcinogenesis has provided a plethora of knowledge regarding cancer. Cancer cells are the product of numerous genetic abnormalities that...
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Nanodelivery in Gene Therapy
Gene therapy stands as a revolutionary approach in medicine, aiming to rectify genetic abnormalities by introducing therapeutic genes or regulating...
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Poor statistical power in population-based association study of gene interaction
BackgroundStatistical epistasis, or “gene–gene interaction” in genetic association studies, means the nonadditive effects between the polymorphic...
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Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival
The plasma cell cancer multiple myeloma (MM) varies significantly in genomic characteristics, response to therapy, and long-term prognosis. To...
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Principles of Therapeutics and Gene-Based Therapy
This chapter focuses on the history and evolution of gene-based therapies from its inception in the early 1970s to the landmark discovery of the...
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Gene Therapy in Molecular Biology and Drug Delivery
The objective of gene therapy is to manipulate/modify the gene expression or modify living cell characteristics for therapeutic utilization. It aims...
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Influence of arsenic exposure and TGF-β gene single nucleotide polymorphisms (gene-environment interaction) on cardiovascular risk biomarkers levels in Mexican people from San Luis Potosi, Mexico
ObjectiveCardiovascular diseases (CVD) are the primary cause of death worldwide. Therefore, this investigation aimed to evaluate the effect of...
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Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses
BackgroundDiabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require...
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Interaction between childhood trauma experience and TPH2 rs7305115 gene polymorphism in brain gray matter volume
BackgroundChildhood trauma is one of the most extensively studied and well-supported environmental risk factors for the development of mental health...
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A systematic analysis of gene–gene interaction in multiple sclerosis
BackgroundFor the most part, genome-wide association studies (GWAS) have only partially explained the heritability of complex diseases. One of their...
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Gene Editing Tool for Neurodegenerative Diseases
Neurodegenerative diseases (NDs) encompass a heterogeneous group of disorders characterized by the progressive degeneration and death of neural...
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Gene–environment interaction between circadian clock gene polymorphisms and job stress on the risk of sleep disturbances
RationaleSleep disturbances was associated with numerous adverse health outcomes. Many studies have reported that long-term exposure to job stress...
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Using machine learning to identify gene interaction networks associated with breast cancer
BackgroundBreast cancer (BC) is one of the most prevalent cancers worldwide but its etiology remains unclear. Obesity is recognized as a risk factor...
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Amyotrophic Lateral Sclerosis-Related Gene Interactions with Fat Mass and Obesity-Associated Gene
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by rapid progressive paralysis and death within a few...
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Amyotrophic Lateral Sclerosis-Related Gene Interactions with Fat Mass and Obesity-Associated Gene
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by rapid progressive paralysis and death within a few...
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Gene expression analysis reveals diabetes-related gene signatures
BackgroundDiabetes is a spectrum of metabolic diseases affecting millions of people worldwide. The loss of pancreatic β-cell mass by either...
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Probing Baculovirus Vector Gene Essentiality for Foreign Gene Expression Using a CRISPR-Cas9 System
The baculovirus expression vector system (BEVS) has now found acceptance in both research laboratories and industry, which can be attributed to many...
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Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP2C19 and non-SSRI/non-TCA antidepressants
The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate pharmacogenetics implementation in clinical practice by develo** evidence-based...
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Microfluidic Approaches for Gene Delivery and Therapy
Gene editing techniques such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) have been developed to target a gene into...