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Theoretical analysis of wake/sleep changes in brain solute transport suggests a flow of interstitial fluid
Clearance of protein waste products from the brain is accomplished by a combination of advection and diffusion in cerebrospinal fluid (CSF) and...
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Transient but not chronic hyperglycemia accelerates ocular glymphatic transport
Glymphatic transport is vital for the physiological homeostasis of the retina and optic nerve. Pathological alterations of ocular glymphatic fluid...
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Cerebrospinal fluid pH regulation
The cerebrospinal fluid (CSF) fills the brain ventricles and the subarachnoid space surrounding the brain and spinal cord. The fluid compartment of...
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Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation
Whether you are reading, running or slee**, your brain and its fluid environment continuously interacts to distribute nutrients and clear metabolic...
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Phytocorrection of Age-Related Changes in the Composition of Blood Plasma, Lymph, and Interstitial Fluid
We studied the effect of a new complex phytocomposition on age-related changes in the composition of biological fluids (blood, lymph, and...
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Nocturnal increase in cerebrospinal fluid secretion as a circadian regulator of intracranial pressure
BackgroundIt is crucial to maintain the intracranial pressure (ICP) within the physiological range to ensure proper brain function. The ICP may...
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Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model
BackgroundSyringomyelia (SM) is characterized by the development of fluid-filled cavities, referred to as syrinxes, within the spinal cord tissue....
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Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier
PurposeThe brain is protected from circulating metabolites and xenobiotics by the blood–brain barrier (BBB) and the blood-cerebrospinal fluid (CSF)...
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Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus
BackgroundDysregulation of brain fluid homeostasis associates with brain pathologies in which fluid accumulation leads to elevated intracranial...
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Tanshinone IIA changed the amniotic fluid volume and regulated expression of AQP1 and AQP3 in amniotic epithelium cells: a promising drug treating abnormal amniotic fluid volume
BackgroundMany studies have confirmed the association of aquaporins (AQPs) with abnormal amniotic fluid volume (AFV). In our previous experiments, we...
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Tear Fluid as a Matrix for Biomonitoring Environmental and Chemical Exposures
PurposeExposures to hazardous chemicals have been linked to many detrimental health effects and it is therefore critical to have effective...
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Are standing osmotic gradients the main driver of cerebrospinal fluid production? A computational analysis
BackgroundThe mechanisms of cerebrospinal fluid (CSF) production by the ventricular choroid plexus (ChP) have not been fully deciphered. One...
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Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain
BackgroundDespite recent attention, pathways and mechanisms of fluid transposition in the brain are still a matter of intense discussion and driving...
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Non-Transport Functions of Aquaporins
Although it has been more than 20 years since the first aquaporin was discovered, the specific functions of many aquaporins are still under...
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Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice
IntroductionThe unbound brain extracelullar fluid (brain ECF ) to plasma steady state partition coefficient, K p,uu,BBB , values provide steady-state...
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Novel localization of folate transport systems in the murine central nervous system
BackgroundFolates are a family of B9 vitamins that serve as one-carbon donors critical to biosynthetic processes required for the development and...
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A Review of Cerebrospinal Fluid Circulation and the Pathogenesis of Congenital Hydrocephalus
The brain’s ventricles are filled with a colorless fluid known as cerebrospinal fluid (CSF). When there is an excessive accumulation of CSF in the...
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Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology
Regulated Na + transport in the distal nephron is of fundamental importance to fluid and electrolyte homeostasis. Further upstream, Na + is the...
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Transport and Excretion of Foreign Compounds
Based on the solubilities in water, foreign compounds that humans ingest or inhale can be classified into two categories: hydrophiles (soluble in...
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Myosin Va-dependent Transport of NMDA Receptors in Hippocampal Neurons
N-methyl-D-aspartate receptor (NMDAR) trafficking is a key process in the regulation of synaptic efficacy and brain function. However, the molecular...
