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New insights into the epitranscriptomic control of pluripotent stem cell fate
Each cell in the human body has a distinguishable fate. Pluripotent stem cells are challenged with a myriad of lineage differentiation options....
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Environmental Toxicology
Environmental toxicology investigates the adverse effects caused by natural and synthetic pollutants in all living organisms of ecosystems and at all...
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Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus
T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR...
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Machine learning-based classification of dual fluorescence signals reveals muscle stem cell fate transitions in response to regenerative niche factors
The proper regulation of muscle stem cell (MuSC) fate by cues from the niche is essential for regeneration of skeletal muscle. How pro-regenerative...
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Tumor Suppressor Genes and Cell Fate Control
In this chapter, we will present the transcription factor p53, which is encoded by the most prominent cancer driver gene, the tumor suppressor gene...
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Three-dimensional genome organization in immune cell fate and function
Immune cell development and activation demand the precise and coordinated control of transcriptional programmes. Three-dimensional (3D) organization...
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How germ granules promote germ cell fate
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble...
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Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle
The balance among quiescence, differentiation, and self-renewal of skeletal muscle stem cells (MuSCs) is tightly regulated by their intrinsic and...
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Dissecting cell fate dynamics in pediatric glioblastoma through the lens of complex systems and cellular cybernetics
Cancers are complex dynamic ecosystems. Reductionist approaches to science are inadequate in characterizing their self-organized patterns and...
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Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination
Toxicant-induced injury is a significant global health issue. However, the mechanisms through which toxicants such as carbon tetrachloride,...
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Review: myogenic and muscle toxicity targets of environmental methylmercury exposure
A number of environmental toxicants are noted for their activity that leads to declined motor function. However, the role of muscle as a proximal...
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Microplastic Occurrence, Fate, Impact, and Remediation
Microplastics and nanoplastics have been recently found in most environmental media and in living organisms, thus representing a serious health...
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Increased proliferation and neuronal fate in prairie vole brain progenitor cells cultured in vitro: effects by social exposure and sexual dimorphism
BackgroundThe prairie vole ( Microtus ochrogaster ) is a socially monogamous rodent that establishes an enduring pair bond after cohabitation, with...
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Bisphenol-F and Bisphenol-S (BPF and BPS) Impair the Stemness of Neural Stem Cells and Neuronal Fate Decision in the Hippocampus Leading to Cognitive Dysfunctions
Neurogenesis occurs throughout life in the hippocampus of the brain, and many environmental toxicants inhibit neural stem cell (NSC) function and...
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Metabolic Pathways in Immune Cells Commitment and Fate
Cellular metabolism, with catabolic and anabolic pathways, is responsible to supply energy and essential molecules involved in cell growth and...
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Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges
The intestinal epithelium is the first line of defense and acts as an interface between the vast microbial world within the gastrointestinal tract...
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