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Combination Drug Strategies for Targeting Specific Biochemical Pathways for Superior Therapeutic Potency
The combination drug therapy is considered as an innovative approach in drug design to reduce the toxicity of the chemotherapeutic drugs while...
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Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients
BackgroundDespite numerous clinical trials and decades of endeavour, there is still no effective cure for Alzheimer's disease. Computational drug...
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Drug conjugates for targeting regulatory T cells in the tumor microenvironment: guided missiles for cancer treatment
Within the tumor microenvironment (TME), regulatory T cells (Tregs) play a key role in suppressing anticancer immune responses; therefore, various...
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Nano-drug delivery system targeting FAP for the combined treatment of oral leukoplakia
Oral leukoplakia (OLK) has received much attention due to its potential risk of malignant transformation. Studies have shown that when drug therapy...
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A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer
Antibody drug conjugate (ADC) therapy has become one of the most promising approaches in cancer immunotherapy. Bispecific targeting could enhance the...
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Targeting EphA2: a promising strategy to overcome chemoresistance and drug resistance in cancer
Erythropoietin-producing hepatocellular A2 (EphA2) is a vital member of the Eph tyrosine kinase receptor family and has been associated with...
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Artificial intelligence-driven new drug discovery targeting serine/threonine kinase 33 for cancer treatment
BackgroundArtificial intelligence (AI) is capable of integrating a large amount of related information to predict therapeutic relationships such as...
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A Multistep In Silico Approach Identifies Potential Glioblastoma Drug Candidates via Inclusive Molecular Targeting of Glioblastoma Stem Cells
Glioblastoma (GBM) is the highest grade of glioma for which no effective therapy is currently available. Despite extensive research in diagnosis and...
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Progress of antibody–drug conjugates (ADCs) targeting c-Met in cancer therapy; insights from clinical and preclinical studies
The cell-surface receptor tyrosine kinase c-mesenchymal-epithelial transition factor (c-Met) is overexpressed in a wide range of solid tumors, making...
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Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance
The tumor microenvironment (TME) plays a pivotal role in cancer development and progression. In this line, revealing the precise mechanisms of the...
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Targeting KRAS mutant cancers: from druggable therapy to drug resistance
Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently mutated oncogene, occurring in a variety of tumor types. Targeting KRAS...
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Trastuzumab for Active Targeting in Cancer Therapy
With the advent of targeted therapies came a new paradigm for cancer treatment. The specific interaction between ligands and surface receptors has...
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Targeting mitophagy for neurological disorders treatment: advances in drugs and non-drug approaches
Mitochondria serve as a vital energy source for nerve cells. The mitochondrial network also acts as a defense mechanism against external stressors...
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A review on lipid-based nanocarriers mimicking chylomicron and their potential in drug delivery and targeting infectious and cancerous diseases
Infectious and cancerous diseases are tedious to manage. The problem of drug resistance is often associated with anti-microbial and anti-cancer...
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Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance
This comprehensive review explores vimentin as a pivotal therapeutic target in cancer treatment, with a primary focus on mitigating metastasis and...
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Ranolazine: a potential anti-metastatic drug targeting voltage-gated sodium channels
BackgroundMulti-faceted evidence from a range of cancers suggests strongly that de novo expression of voltage-gated sodium channels (VGSCs) plays a...
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Recent Advances in FDA-Approved Kinase Inhibitors Targeting Lung Cancer
Lung cancer is a chronic deadly disease and is implicated with highest mortality rate among all cancers since years. Kinase are the...
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Therapeutic Targeting of Potassium Channels
Potassium (K+) channels are the largest group of ion channels in mammals. The immediate function of these channels is electrogenic transport of K+...
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A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
Leveraging the specificity of antibody to deliver cytotoxic agent into tumor, antibody-drug conjugates (ADCs) have become one of the hotspots in the...
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Nano-Based Drug Delivery Systems
Nanoparticles are important for refining drug delivery. There has been a considerable increase in the number of new biotechnology-based therapeutics....