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Dopaminergic and adrenergic receptors synergistically stimulate browning in 3T3-L1 white adipocytes
The browning of white adipose tissue (WAT) has attracted considerable attention in the scientific community as a popular strategy for enhancing...
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Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway
RationaleClinical studies have revealed that methamphetamine abuse increases risk for develo** Parkinson’s diseases. It is thus important to...
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Dopaminergic Receptors as Neuroimmune Mediators in Experimental Autoimmune Encephalomyelitis
The dopaminergic system plays an essential role in maintaining homeostasis between the central nervous system (CNS) and the immune system. Previous...
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Neural targets of the enteric dopaminergic system in regulating motility of rat proximal colon
In isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes a dilatation, while the D 1 -like receptor...
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The Dopaminergic System Modulates the Electrophysiological Activity of the Suprachiasmatic Nucleus Dependent on the Circadian Cycle
The suprachiasmatic nucleus of the hypothalamus (SCN) controls mammalian circadian rhythms. Circadian rhythms influence the dopaminergic system, and...
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A Study of Dopaminergic Pathway in Neurologic Wilson Disease with Movement Disorder
Movement disorder (MD) is an important manifestation of neurologic Wilson disease (NWD), but there is a paucity of information on dopaminergic...
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Mycotherapeutics Affecting Dopaminergic Neurotransmission to Exert Neuroprotection
Alternative or integrative medicine is a holistic approach to healthcare that has been used for centuries in many different cultures. Today, there is...
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Mood and behavior regulation: interaction of lithium and dopaminergic system
Lithium is one of the most effect mood-stabilizing drugs prescribed especially for bipolar disorder. Lithium has wide range effects on different...
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The cerebellum directly modulates the substantia nigra dopaminergic activity
Evidence of direct reciprocal connections between the cerebellum and basal ganglia has challenged the long-held notion that these structures function...
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Intersection of hippocampus and spinal cord: a focus on the hippocampal alpha-synuclein accumulation, dopaminergic receptors, neurogenesis, and cognitive function following spinal cord injury in male rats
BackgroundFollowing Spinal Cord Injury (SCI), innumerable inflammatory and degenerative fluctuations appear in the injured site, and even remotely in...
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Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction
Peri-operative hemorrhagic shock and resuscitation (HSR), a severe traumatic stress, is closely associated with post-operative anxiety, depression,...
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Investigations of brain-wide functional and structural networks of dopaminergic and CamKIIα-positive neurons in VTA with DREADD-fMRI and neurotropic virus tracing technologies
BackgroundThe ventral tegmental area (VTA) contains heterogeneous cell populations. The dopaminergic neurons in VTA play a central role in reward and...
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Locomotor Behavior and Memory Dysfunction Induced by 3-Nitropropionic Acid in Adult Zebrafish: Modulation of Dopaminergic Signaling
Huntington’s disease (HD) is a progressive neurodegenerative disease characterized by neuropsychiatric disturbance, cognitive impairment, and...
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Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans
Progressive neurodegenerative disorders such as Parkinson Disease (PD) lack curative or long-term treatments. At the same time, the increase of the...
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Perspectives for Dopaminergic Therapy in Multiple Sclerosis
Dopamine is a direct mediator of neuroimmune interactions. Studies in recent years have shown that actions on dopamine receptors can potentially...
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Exploring the levodopa-paradox of freezing of gait in dopaminergic medication-naïve Parkinson’s disease populations
The relationship between dopaminergic treatment and freezing of gait (FOG) in Parkinson’s disease (PD) is complex: levodopa is the most effective...
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Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity
BackgroundNoradrenergic neurons in the locus coeruleus (LC) are the primary source of norepinephrine (NE) in the brain and degeneration of these...
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Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson’s disease mouse model through activating GHS-R1a/D2R heterodimers
Growth hormone secretagogue receptor 1a (GHS-R1a) is an important G protein-coupled receptor (GPCR) that regulates a variety of functions by binding...
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Differential Roles of the D1- and D2-Like Dopamine Receptors Within the Ventral Tegmental Area in Modulating the Antinociception Induced by Forced Swim Stress in the Rat
Several preclinical and clinical studies indicate that exposure to acute stress may decrease pain perception and increases pain tolerance. This...
