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Domperidone inhibits cell proliferation via targeting MEK and CDK4 in esophageal squamous cell carcinoma
BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the leading causes of digestive system tumor related death in the world. Unfortunately,...
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Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis
BackgroundChronic kidney disease (CKD) represents the main cause of mortality in dogs with leishmaniosis. Domperidone has recently been reported to...
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Evaluation of domperidone efficacy to prevent aspiration pneumonia in patients with acute ischemic stroke: a randomized clinical trial
Background and aimAspiration pneumonia is an essential complication of acute ischemic stroke (AIS), which is responsible for increased three-fold...
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HPLC-Fluorescence Detection Method for Concurrent Estimation of Domperidone and Naproxen. Validation and Eco-Friendliness Appraisal Studies
This work demonstrates a simple and reliable HPLC method with fluorimetric detection for simultaneous estimation of domperidone (DOM) and naproxen...
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Effect of domperidone (leisguard®) on antibody titers, inflammatory markers and creatinine in dogs with leishmaniosis and chronic kidney disease
BackgroundImmunotherapeutic drugs, such as domperidone, have been shown to be promising treatments against canine leishmaniosis (CanL), but limited...
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A blinded, randomized and controlled multicenter clinical trial to assess the efficacy and safety of Leisguard® as an immunotherapeutic treatment for healthy Leishmania infantum-seropositive dogs
BackgroundDomperidone (Leisguard ® ) is an immunomodulatory drug used as a preventive measure in healthy dogs. However, no studies have been published...
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Domperidone nanocrystals with boosted oral bioavailability: fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction
The aim of this study was to employ experimental and molecular modelling approaches to use molecular level interactions to rationalise the selection...
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Drug utilisation in neonatal units in England and Wales: a national cohort study
PurposeTo describe drug utilisation patterns in neonatal units.
MethodsRetrospective observational cohort study using data held in the National...
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The Period of Established Lactation: Lactogenesis III
During the period of steady-state lactation (lactogenesis III), the content of milk components, the dynamics of their concentrations, and the rate of...
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Antiemetics
Emesis is defined as a forceful emptying of contents of stomach and intestines due to stimulation of emesis centre. Nausea is defined as ‘unpleasant...
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Drugs Affecting Gastrointestinal Motility
Gastrointestinal (GI) motility is an essential function of the gastrointestinal tract, which is regulated by various neurohumoural factors and drugs....
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Diagnosis and clinical management of canine leishmaniosis by general veterinary practitioners: a questionnaire-based survey in Portugal
BackgroundCanine leishmaniosis (CanL) can be appropriately managed following international recommendations. However, few studies have assessed the...
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Longer-term breastfeeding outcomes associated with domperidone use for lactation differs according to maternal weight
PurposeTo examine differences in longer-term breastfeeding outcomes among mothers of preterm infants according to domperidone exposure status, as...
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New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection
Since the early 1990s, when Robert’s and Szabo’s cytoprotection concept had already been more than one decade old, but still not implemented in...
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Drug-drug interaction perpetrators of oxycodone in patients with cancer: frequency and clinical relevance
AimOxycodone is known to have numerous drug-drug interactions (DDIs) that can potentially decrease efficacy or lead to adverse drug reactions (ADRs)....
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Domperidone prolongs oral to duodenal transit time in video capsule endoscopy
PurposeDomperidone is thought to accelerate gastric emptying via D2 receptor antagonism at the gastro-oesophageal and gastro-duodenal junctions....