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Aminophylline at clinically relevant concentrations affects inward rectifier potassium current in a dual way
Bronchodilator aminophylline may induce atrial or less often ventricular arrhythmias. The mechanism of this proarrhythmic side effect has not been...
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Altered neuronal excitability in a Hodgkin-Huxley model incorporating channelopathies of the delayed rectifier potassium channel
Channelopathies involving acquired or genetic modifications of the delayed rectifier K + channel Kv1.1 include phenotypes characterized by enhanced...
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Therapeutic Targeting of Potassium Channels
Potassium (K+) channels are the largest group of ion channels in mammals. The immediate function of these channels is electrogenic transport of K+...
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Clenbuterol-sensitive delayed outward potassium currents in a cell model of spinal and bulbar muscular atrophy
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by polyglutamine (polyQ) expansions in the androgen receptor (AR) gene....
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Single Neuron Modeling Identifies Potassium Channel Modulation as Potential Target for Repetitive Head Impacts
Traumatic brain injury (TBI) and repetitive head impacts can result in a wide range of neurological symptoms. Despite being the most common...
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Characterization and functional role of rapid- and slow-activating delayed rectifier K+ currents in atrioventricular node cells of guinea pigs
The atrioventricular (AV) node is the only conduction pathway where electrical impulse can pass from atria to ventricles and exhibits spontaneous...
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The Dependence of the Electrophysiological Effects of Class III Antiarrhythmic Drug Refralon on the Frequency of Myocardium Activation
We studied the frequency dependence of the effects of the novel Russian class III antiarrhythmic drug refralon on the duration of action potentials...
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The electrophysiological effects of cannabidiol on action potentials and transmembrane potassium currents in rabbit and dog cardiac ventricular preparations
Cannabis use is associated with known cardiovascular side effects such as cardiac arrhythmias or even sudden cardiac death. The mechanisms behind...
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Hypoxia with inflammation and reperfusion alters membrane resistance by dynamically regulating voltage-gated potassium channels in hippocampal CA1 neurons
Hypoxia typically accompanies acute inflammatory responses in patients and animal models. However, a limited number of studies have examined the...
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Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome type 7
ObjectiveLong QT syndrome type 7 (Andersen–Tawil syndrome, ATS), which is caused by KCNJ2 gene mutation, often leads to ventricular arrhythmia,...
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Kv11.1 (hERG1) Channels and Cardiac Arrhythmia
The rapid delayed rectifier K+ current (IKr) is one of several outward currents that mediate repolarization of cardiac action potentials in humans...
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Detection of a novel pathogenic variant in KCNH2 associated with long QT syndrome 2 using whole exome sequencing
BackgroundLong QT syndrome (LQTS) is a cardiac channelopathy characterized by impaired myocardial repolarization that predisposes to life-threatening...
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Single-compartment model of a pyramidal neuron, fitted to recordings with current and conductance injection
For single neuron models, reproducing characteristics of neuronal activity such as the firing rate, amplitude of spikes, and threshold potentials as...
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Cardiovascular Safety Assessment of New Chemical Entities: Current Perspective and Emerging Technologies
The origin of cardiovascular (CVS) safety assessment studies was marked with the constitution of ICH guidelines that govern the majority of...
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TPEN attenuates amyloid-β25–35-induced neuronal damage with changes in the electrophysiological properties of voltage-gated sodium and potassium channels
To understand the role of intracellular zinc ion (Zn 2+ ) dysregulation in mediating age-related neurodegenerative changes, particularly neurotoxicity...
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Effects of hydrogen sulfide on relaxation responses in the lower esophageal sphincter in rabbits: the potential role of potassium channels
Hydrogen sulfide (H 2 S) is a significant physiologic inhibitory neurotransmitter. The main goal of this research was to examine the contribution of...
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Effects of miR-34c-5p on Sodium, Potassium, and Calcium Channel Currents in C2C12 Myotubes
The aim of this study was to investigate the effects of miR-34c-5p on the main voltage-dependent ion channels in skeletal muscle cells. This study...
