Search
Search Results
-
Genomics in Treatment Development
The Human Genome Project mapped the 3 billion base pairs in the human genome, which ushered in a new generation of genomically focused treatment...
-
A Pharmacogenomics-Based In Silico Investigation of Opioid Prescribing in Post-operative Spine Pain Management and Personalized Therapy
AbstractConsidering the variability in individual responses to opioids and the growing concerns about opioid addiction, prescribing opioids for...
-
In-silico mining to glean SNPs of pharmaco-clinical importance: an investigation with reference to the Indian populated SNPs
Drugs pharmacology is defined by pharmacokinetics and pharmacodynamics and both of them are affected by genetic variability. Genetic variability...
-
The Effects of AT-533 and AT-533 gel on Liver Cytochrome P450 Enzymes in Rats
Background and ObjectivesAT-533 is a novel heat shock protein 90 inhibitor, which exhibits various biological activities in vitro and in vivo....
-
Pharmacogenetics: A New Approach for the Selection of the Right Drug
Pharmacogenetics is the study of genes and the way an individual will respond to a particular drug. It is an advanced branch of medicine where the...
-
Drug Interactions
Drug-drug interactions (DDIs) are considered as change of drug-related effects due to the simultaneous administration of another drug. As a...
-
Drug Interactions
Drug-drug interactions (DDIs) are considered as change of drug-related effects due to the simultaneous administration of another drug. As a...
-
Maternal and Fetal Expression of ATP-Binding Cassette and Solute Carrier Transporters Involved in the Brain Disposition of Drugs
Evidence from preclinical and clinical studies demonstrate that pregnancy is a physiological state capable of modifying drug disposition. Factors...
-
Significance of Stability and Pharmacokinetic Issues in Traditional Medicine
Herbal medicine has become the backbone of the traditional medicine in recent years. There is an increase in demand in the global market and...
-
Frequencies of CYP2D6 genetic polymorphisms in Arab populations
CYP2D6 is a key drug-metabolizing enzyme implicated in the biotransformation of approximately 25% of currently prescribed drugs. Interindividual and...
-
An Insight into Herb Interactions: Clinical Evidence-Based Overview
Medicines are used for betterment of human health, and huge number of human population uses medicines for the same. But the desired effects of these...
-
Eighth pharmacologic-historical forum
Scope, historical overview and perspectivesAthineos Philippu, Department of Pharmacology and Toxicology, University of Innsbruck, Austria
...
-
Physiologically based pharmacokinetic model predictions of natural product-drug interactions between goldenseal, berberine, imatinib and bosutinib
PurposeThis study implements a physiologically based pharmacokinetic (PBPK) modelling approach to predict the effect of hydrastine and berberine, two...
-
Toxicodynamic Tests
Toxicodynamic testing is aimed at the elucidation of adverse effects of chemicals including understanding of their mode of action. In many cases, the...
-
Toxicodynamic Tests
Toxicodynamic testing is aimed at the elucidation of adverse effects of chemicals including understanding of their mode of action. In many cases, the...
-
Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications
Neurogenesis is the process by which new neurons are generated from neural stem cells (NSCs), which are cells that have the ability to proliferate...
-
A Systematic Review of Drug Metabolism Studies of Plants With Anticancer Properties: Approaches Applied and Limitations
Background and ObjectivesHepatic drug metabolism is a key influence on the efficacy and safety of medicines from both chemical and natural product...
-
Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrate overlap** shifts in the colonic mucosal-luminal interface microbiome
BackgroundCrohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unaffected...
-
Pharmacogenetics in clinical practice: current level of knowledge among Flemish physicians and pharmacists
Over the past decade, pharmacogenetics (PGx) became an essential tool for personalized medicine although its clinical implementation is still...
