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Neural targets of the enteric dopaminergic system in regulating motility of rat proximal colon
In isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes a dilatation, while the D 1 -like receptor...
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Colonic Response to Physiological, Chemical, Electrical and Mechanical Stimuli; What Can Be Used to Define Normal Motility?
The colon plays an important functional role in the bacterial fermentation of carbohydrates, transmural exchange of fluid and short-chain fatty...
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Muscarinic Regulation of Gastrointestinal Motility
In the mammalian gastrointestinal tract, acetylcholine is the primary excitatory neurotransmitter that binds to and stimulates muscarinic receptors...
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Effect of Reactive EGCs on Intestinal Motility and Enteric Neurons During Endotoxemia
Paralytic ileus is common in patients with septic shock, causing high morbidity and mortality. Enteric neurons and enteric glial cells (EGCs)...
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Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model
Several studies have identified the effects of methamphetamine (MA) on central dopaminergic neurons, but its effects on enteric dopaminergic neurons...
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Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms
Gut microbiota is closely related to human health and disease because, together with their metabolites, gut microbiota maintain normal intestinal...
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The mechanisms of nerve injury caused by viral infection in the occurrence of gastrointestinal motility disorder-related diseases
Gastrointestinal motility refers to the peristalsis and contractility of gastrointestinal muscles, including the force and frequency of...
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Dopamine and Gastrointestinal Motility
Dopamine (DA) plays an important role in regulating gastrointestinal (GI) motility function, from the esophagus to the colon. In this chapter, we...
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Circadian Control of Gastrointestinal Motility
With the earth’s 24-h rotation cycle, physiological function fluctuates in both diurnal and nocturnal animals, thereby ensuring optimal functioning...
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MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3β/β-Catenin Signaling and Induce Enteric Glial Cell Apoptosis
Enteric glial cells (EGCs) are the major component of the enteric nervous system and affect the pathophysiological process of intestinal motility...
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Exploring extracellular matrix and prostaglandin pathway alterations across varying resection margin distances of right-sided colonic adenocarcinoma
BackgroundSurgical resection followed by indicated adjuvant therapy offers potential curative treatment in colonic adenocarcinoma. Beyond the...
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Role of PGE2 in colonic motility: PGE2 attenuates spontaneous contractions of circular smooth muscle via EP4 receptors in the rat colon
Colonic motor activity is important for the formation and propulsion of feces. The production of prostaglandins (PGs) in colonic tissue is considered...
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Drugs Affecting Gastrointestinal Motility
Gastrointestinal (GI) motility is an essential function of the gastrointestinal tract, which is regulated by various neurohumoural factors and drugs....
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Microbial regulation of intestinal motility provides resistance against helminth infection
Soil-transmitted helminths cause widespread disease, infecting ~1.5 billion people living within poverty-stricken regions of tropical and subtropical...
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Upper Gastrointestinal Motility, Disease and Potential of Stem Cell Therapy
Many gastrointestinal motility disorders arise due to defects in the enteric nervous system. Achalasia and gastroparesis are two extremely...
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New Concepts of the Interplay Between the Gut Microbiota and the Enteric Nervous System in the Control of Motility
Propulsive gastrointestinal (GI) motility is critical for digestive physiology and host defense. GI motility is finely regulated by the intramural...
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Intermittent colonic exoperistalsis for chronic constipation in spinal cord-injured individuals. A long-term structured patient feedback survey to evaluate home care use
Study designStructured patient feedback survey evaluating real-world home care use.
ObjectivesTo assess the long-term effectiveness, tolerability,...
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Inhibitory Effects of Dexmedetomidine and Propofol on Gastrointestinal Tract Motility Involving Impaired Enteric Glia Ca2+ Response in Mice
Propofol and dexmedetomidine are popular used for sedation in ICU, however, inadequate attention has been paid to their effect on gastrointestinal...
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Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain
Visceral pain is a prominent feature of various gastrointestinal diseases. The P2X7 receptor is expressed by multiple cell types including dorsal...
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5-HT4 Receptor is Protective for MPTP-induced Parkinson’s Disease Mice Via Altering Gastrointestinal Motility or Gut Microbiota
Serotonergic dysfunction is related to both motor and nonmotor symptoms in Parkinson’s disease (PD). As a 5-HT receptor, 5-HT4 receptor (5-HT4R) is...
